Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The discovery of a role for EIF3F-STAT3 interaction in the genetic control of cell migration and metastasis in human lung adenocarcinoma could lead to the development of diagnosis and therapeutic strategies.
|
31527668 |
2020 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3-specific shRNAs significantly re-sensitized TRIM59-proficient EGFR mutant lung adenocarcinoma cells to gefitinib.
|
30902544 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ultimately, STAT3 was identified to decrease lung adenocarcinoma cell viability, survival, apoptosis and EMT imposed by miR‑29b‑3p.
|
30747209 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We further found that increased mRNA expressions of STAT2 and STAT3 predicted unfavorable overall survival (OS) while high mRNA expression of STAT5B and STAT6 related to favorable OS for lung ADE patients.
|
31497205 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, we reveal that MPC1/STAT3 axis plays an important role in the progression of LAC, and our work may promote the development of new therapeutic strategies for LAC.
|
30770798 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that the STAT3 pathway may be implicated in the DHX9-related epithelial-mesenchymal transition of lung adenocarcinoma.
|
31497206 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
AM-derived EVs containing SOCS3 inhibited STAT3 activation as well as proliferation and survival of lung adenocarcinoma cells.
|
31619584 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TRIM11 promotes tumor angiogenesis via activation of STAT3/VEGFA signaling in lung adenocarcinoma.
|
31598402 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
15-Lipoxygenase-2/15(S)-hydroxyeicosatetraenoic acid regulates cell proliferation and metastasis via the STAT3 pathway in lung adenocarcinoma.
|
30110652 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
CuI (0.1-10 mmol/L) dose-dependently inhibited the phosphorylation of STAT3, and enhanced the phosphorylation of STAT1 in lung adenocarcinoma A549 cells possibly through disrupting actin filaments.
|
29119966 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of JAK2 or signal transducer and activator of transcription 3 (STAT3) activity with small chemical inhibitors in A549 cells impaired lung adenocarcinoma angiogenesis in vitro.
|
29281186 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3 activation compensated for ARHGAP35 knockdown in lung adenocarcinoma with the KRAS mutation.
|
30015929 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma.
|
28879441 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells.
|
28608828 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma.
|
27893707 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We further show that ACK1 promotes the phosphorylation and nuclear accumulation of STAT3 in cultured cells and that the levels of ACK1 correlate positively with the levels of tyrosine phosphorylated STAT3 in primary lung adenocarcinoma (ADC) cells.
|
28739485 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
|
28115165 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Two STAT3 siRNAs decreased PD-L1 expression by 10-32% in two of the three KRAS-mutant lung adenocarcinoma cell lines (p < 0.05), while the PI3K inhibitor LY294002 (40 μM) did not change the expression level.
|
27846317 |
2016 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, chemotherapy-induced IL-11 upregulation in CAF promotes lung adenocarcinoma cell chemoresistance by activating IL-11R/STAT3 anti-apoptotic signaling pathway.
|
27922075 |
2016 |
Adenocarcinoma of lung (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results elucidate a novel STAT3-NF-κB-IL-8 axis in KRAS mutant AC with therapeutic and prognostic relevance.
|
25734337 |
2015 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
STAT3 expression in activating EGFR-driven adenocarcinoma of the lung.
|
21684622 |
2012 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aims of the present study were to evaluate STAT3 activation (p-STAT3 protein levels) in lung adenocarcinoma and squamous cell carcinoma, and to investigate its correlation with clinicopathologic features of these malignancies.
|
22208386 |
2011 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibitors of Jak2/Stat3, MEK/Erk and PI3-K/Akt pathways down-regulated IL-6 secretion in the lung adenocarcinoma PC14PE6/AS2 (AS2) cells, which spontaneously secreted IL-6 and possessed constitutively activated Stat3.
|
21122157 |
2010 |
Adenocarcinoma of lung (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that the JAK2/STAT3 pathway is involved in the IL-6-mediated regulation of MMP-10, and IL-6 can moderately reduce MMP-10 mRNA levels and strongly increase MMP-10 protein mass in human lung adenocarcinoma A549 cells.
|
20032397 |
2009 |
Adenocarcinoma of lung (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stat3 and its downstream genes can serve as biomarkers for lung adenocarcinoma and COPD diagnosis and prognosis in mice and humans.
|
18614255 |
2009 |