|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
The further assay showed that STAT3 was a target of miR-125b in cervical cancer.
|
30246459 |
2019 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that the HPV encoded E6 protein increases the activity of the proto-oncogenic transcription factor STAT3 in primary human keratinocytes; however, the molecular basis for STAT3 activation in cervical cancer remains unclear.
|
31226168 |
2019 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression of signal transducers and activators of transcription 3 (STAT3) was downregulated after overexpressing LINC00052 in cervical cancer cells.
|
31210293 |
2019 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which regulates a variety of cancer cellular physiological activities including cervical cancer.
|
31616177 |
2019 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The clinical value of HPV E6/E7 and STAT3 mRNA detection in cervical cancer screening.
|
29655523 |
2018 |
|
cervical cancer
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cervical cancer was divided into two groups upon STAT3 median level.
|
30024597 |
2018 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
While, inhibition of miR-29b could prevent the cisplatin-induced epithelial features, cell movement and angiogenesis of CC cells, which means miR-29b/STAT3 axis participates in the chemotherapy of cisplatin in CC.
|
28122338 |
2017 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
A-to-I RNA editing of BLCAP lost the inhibition to STAT3 activation in cervical cancer.
|
28455960 |
2017 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the contribution of STAT3 activity to TRAIL-induced apoptosis in cervical cancer remains unknown.
|
27599897 |
2016 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Clinically, STAT3, the expression of which, predicted poorer outcome, was inversely correlated with miR-125a in cervical cancer.
|
26389681 |
2015 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-γ with cervical cancer susceptibility in Chinese Han women in Hunan province.
|
25921106 |
2015 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
SHP2, PIAS3, and SOCS3 are STAT3 negative regulators; therefore, their statuses in cervical adenocarcinoma (HeLa) and squamous cell carcinoma (SiHa and C33A) cell lines without and with resveratrol treatment and their correlation with STAT3 activation in CC specimens were investigated.
|
26432044 |
2015 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
CTD_human |
Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.
|
25061499 |
2014 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for management of cervical cancer.
|
25539644 |
2014 |
|
cervical cancer
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leads obtained from the present study provide a strong rationale for developing novel STAT3-based approaches for therapeutic interventions against HPV infection to control cervical cancer.
|
23874455 |
2013 |
|
cervical cancer
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Collectively, these findings suggested that STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women.
|
21668356 |
2011 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarly, a high level of constitutively active STAT3 expression was observed in HPV-positive cervical cancer cell lines when compared to that of HPV-negative cells.
|
20977777 |
2010 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.
|
19642906 |
2009 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Tissue biopsies from 100 patients with cervical cancer of different stages and normal tissues from patients undergoing hysterectomy were selected for studying the HPV status and STAT3 expression.
|
19421717 |
2009 |
|
cervical cancer
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the constitutive activation of Stat3 in endometrial and cervical cancers has not been studied.
|
17311011 |
2007 |