|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, STAT3-mediated immunosuppression is crucial for metastasis.
|
31848193 |
2020 |
|
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) transcription factor has been observed in many human cancers with roles in tumor initiation, progression, drug resistance, angiogenesis and immunosuppression.
|
31361777 |
2019 |
|
Immunosuppression
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, Western blot analysis showed that higher immunosuppression decreased phosphorylation of signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells-p65, increased phosphorylation of extracellular-signal-regulated kinase, and reduced the expression of Bcl-2-associated X protein and caspase-3 in the renal allografts.
|
30152136 |
2019 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, targeting STAT3 holds the potential of reversing immunosuppression in cancer.
|
31348843 |
2019 |
|
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Apart from its oncogenic role in regulating gene expression in tumor cells, STAT3 also paves the way for human cancer growth through immunosuppression.
|
29222039 |
2018 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of signal transducer and activator of transcription 3 (STAT3) in TAM lead to tumor-induced immunosuppression.
|
30197360 |
2018 |
|
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, some preclinical trial data suggest that addition of immunomodulatory reagents such as immune checkpoint inhibitors, transforming growth factor-β inhibitors, signal transducer and activator of transcription 3 inhibitors, or modifiers of tryptophan metabolism could augment the therapeutic activity of vaccination and overcome glioma-associated immunosuppression.
|
28497804 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3 is considered to be a key molecule to mediating tumor-induced immunosuppression in various manners at tumor sites, by acting through immune-regulatory cytokines derived from the tumor cells.
|
28716484 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that rapamycin treatment inhibits the mTOR-STAT3 pathway in EAE mice, thereby promoting immunosuppression.
|
28600752 |
2017 |
|
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CTLA4-CD86 ligation recruited and activated the JAK family member Tyk2, resulting in STAT3 activation and expression of genes critical for cancer immunosuppression and tumor growth and survival.
|
28716895 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC.
|
28605599 |
2017 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In in vitro and in vivo studies, including studies on humans, selective STAT3 inhibitors such as Stattic and S3I-201 have demonstrated potential in regulating MDSC-mediated immunosuppression.
|
27572156 |
2016 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: a plausible regional mechanism of immunosuppression in arsenical cancers.
|
25559853 |
2015 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upon upregulating miR-124 in glioma cancer stem cells (gCSC), the STAT3 pathway was inhibited, and miR-124 reversed gCSC-mediated immunosuppression of T-cell proliferation and induction of forkhead box P3 (Foxp3)(+) regulatory T cells (Treg).
|
23636127 |
2013 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activation of signal transducer and activator of transcription signaling 3 (STAT3) has been linked with the survival, proliferation, angiogenesis and immunosuppression of hepatocellular carcinoma cells (HCCs).
|
23032719 |
2013 |
|
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT3 is known to play critical roles in tumorigenesis and cancer-induced immunosuppression.
|
22210182 |
2012 |