Disease: Leukemia, Large Granular Lymphocytic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1522378
Disease: Leukemia, Large Granular Lymphocytic
Leukemia, Large Granular Lymphocytic 		0.330 Biomarker disease CTD_human STAT5BN642H is a driver mutation for T cell neoplasia. 29200404 2018
CUI: C1522378
Disease: Leukemia, Large Granular Lymphocytic
Leukemia, Large Granular Lymphocytic 		0.330 GeneticVariation disease BEFREE We observed activating STAT5B mutations (1/5) and hypermethylation of HACE1 (3/4) in ANKL cases, suggesting that these aberrations may contribute to ANKL pathogenesis. 26975038 2016
CUI: C1522378
Disease: Leukemia, Large Granular Lymphocytic
Leukemia, Large Granular Lymphocytic 		0.330 Biomarker disease CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916 2015
CUI: C1522378
Disease: Leukemia, Large Granular Lymphocytic
Leukemia, Large Granular Lymphocytic 		0.330 GeneticVariation disease BEFREE STAT3 and STAT5b mutations can be used as molecular markers for LGL leukemia diagnostics, and they present novel therapeutic targets for STAT3 and STAT5b inhibitors, which currently are in development for treatment of cancer and autoimmune disorders. 24512550 2014
CUI: C1522378
Disease: Leukemia, Large Granular Lymphocytic
Leukemia, Large Granular Lymphocytic 		0.330 GeneticVariation disease BEFREE This is the first time somatic STAT5 mutations are discovered in human cancer and further emphasizes the role of STAT family genes in the pathogenesis of LGL leukemia. 23596048 2013