|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, the significant gene-gene interactions among IL-4 -C33T, IL-13 R130Q, IL-4Ralpha I75V, IL-4Ralpha Q576R, STAT6 C2892T, and CD14 -C159T may increase an individual's susceptibility to asthma and contribute to the pathogenesis of asthma.
|
20394509 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Direct sequencing analysis revealed that the 13 GT repeat allelic variation in noncoding exon 1 of the STAT6 gene appeared more frequently in 91 patients with asthma or rheumatoid arthritis than the 15 GT repeat variation, which is the dominant phenotype in healthy controls.
|
19949830 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have studied the association of polymorphism rs4795405 in ORMDL3, rs324011 in STAT6 as well as rs8113232 and rs3786989 in TBXA2R with asthma risk, various asthma phenotypes and asthma-related symptoms.
|
22017802 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Home dampness combined with each one of the genes STAT6, IL13 and ADRB2 could raise the asthma risk.
|
22355322 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation.
|
14735150 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In Egyptian children, the IL-4Rα and the STAT6 polymorphism may play a role in susceptibility to AD.
|
24742632 |
2014 |
|
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We used data from the Han Chinese in Beijing genome panel of International HapMap Project and the Taiwan Children Health Study cohort to investigate the association of STAT6 genetic variants and childhood AD risks.
|
26048407 |
2015 |
|
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, there was a significant association between genotype and allele frequencies of the STAT6 (G2946A) polymorphism in the non-AD (P < 0.05) and AD (P < 0.01) groups.
|
27018548 |
2016 |
|
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We undertook an association study between these variants of the STAT6 gene and allergic diseases, including atopic dermatitis, bronchial asthma, and food-related anaphylaxis in a Japanese population.
|
12759487 |
2003 |
|
hemangiopericytoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Clinicopathological data, including yearly follow-ups, are required for meningeal SFTs/HPCs to define the correlation of variants of NAB2-STAT6 fusion gene.
|
27271270 |
2016 |
|
hemangiopericytoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The 2016 central nervous system (CNS) World Health Organisation (WHO) Update has merged the entities of meningeal solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) into a single entity based on the presence of the nerve growth factor 1A (NGFI-A) binding protein 2 (NAB2)- signal transducer and activator of transcription 6 (STAT6) gene fusion in these tumors.
|
30233017 |
2019 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, there was a significant association between genotype and allele frequencies of the STAT6 (G2946A) polymorphism in the non-AD (P < 0.05) and AD (P < 0.01) groups.
|
27018548 |
2016 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We used data from the Han Chinese in Beijing genome panel of International HapMap Project and the Taiwan Children Health Study cohort to investigate the association of STAT6 genetic variants and childhood AD risks.
|
26048407 |
2015 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We undertook an association study between these variants of the STAT6 gene and allergic diseases, including atopic dermatitis, bronchial asthma, and food-related anaphylaxis in a Japanese population.
|
12759487 |
2003 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study adds to the current knowledge of genetic susceptibility by demonstrating for the first time an interactive effect between SNPs in IL13 (rs20541) and STAT6 (rs1059513) on the occurrence of eczema in two independent samples.
|
23815671 |
2013 |
|
Eczema
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In Egyptian children, the IL-4Rα and the STAT6 polymorphism may play a role in susceptibility to AD.
|
24742632 |
2014 |
|
Eosinophilic esophagitis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci, ANKRD27 that regulates the trafficking of melanogenic enzymes to epidermal melanocytes and CAPN14, that encodes a calpain whose expression is highly enriched in the oesophagus.
|
25407941 |
2014 |
|
Eosinophilic esophagitis
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies four novel eosinophilic esophagitis loci.
|
25407941 |
2014 |
|
Eosinophilic esophagitis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Common variants in CYP2C19 and STAT6 associate with a PPI-nonresponsive EoE outcome of PPI therapy for esophageal eosinophilia suggesting that response rates may be improved by adopting a genotype-guided approach to PPI dosing.
|
31490856 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Childhood asthma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The MDR analysis showed that GT repeats, C258T and T710C of STAT6 polymorphisms interacted together in leading to susceptibility to childhood asthma among Chinese people.
|
22365404 |
2011 |
|
Childhood asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |