|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.
|
31424136 |
2020 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we described a cohort of 41 patients with solitary fibrous tumor of the extremities and evaluated the prognostic role of clinical and histological features, presence of C228T and C250T mutations at the TERT promoter region, and NAB2-STAT6 fusion variants.
|
31463729 |
2020 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
STAT6 Monoclonal Antibody is Highly Specific for the Distinction between Solitary Fibrous Tumour and Prostatic Stromal Proliferations.
|
31498908 |
2020 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
The tumor cells of both components showed nuclear relocalization of the signal transducer and activator of transcription 6 protein, with very high specificity and sensitivity for the diagnosis of SFT/HPC.
|
30864263 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The derived immunohistochemical detection of nuclear STAT6 expression has high diagnostic value in distinguishing SFTs from histologic mimics, although some relevant pitfalls have been proposed as a precaution.
|
30431144 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monoclonal STAT6 stain is highly sensitive and specific for SFTs and particularly useful in the diagnosis of difficult SFT cases.
|
30664532 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms.
|
31321477 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objectives were to review the cases diagnosed as meningeal SFT or HPC between 2010 and 2017 and classify them into SFT (grade I) or HPC (grades II and III) phenotypes; to confirm the diagnosis by performing STAT6 immunohistochemistry; and to observe and record the histological features in detail and correlate the tumor grades with their behavior.
|
30233017 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
STAT6 immunohistochemistry is recommended to confirm the diagnosis of SFT in the pediatric population.
|
29228868 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This review addresses three main neoplastic categories that are associated with specific paraneoplastic phenomena: (1) neoplasms having in common the presence of diffuse mixed inflammatory infiltration (closely simulating an inflammatory pseudotumor) and frequently associated with constitutional symptoms; (2) neoplasms with undifferentiated, anaplastic or rhabdoid cell morphology (frequently SWI/SNF-deficient) associated with diverse paraneoplastic manifestations; and (3) paraneoplasia associated with neoplasms carrying specific gene fusions such as solitary fibrous tumor (STAT6-NAB2 gene fusions), infantile fibrosarcoma and congenital mesoblastic nephroma (ETV6-NTRK3 gene fusions), and angiomatoid fibrous histiocytoma (EWSR1-CREB1 & EWSR1-ATF1 fusions).
|
30819530 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here, we present the results of a study that analyzed the prognostic value of an updated version of the Marseille Grading System (MGS) in a retrospectively assembled cohort of 132 primary meningeal SFTs/HPCs with nuclear overexpression of STAT6.
|
29600523 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
It exemplifies the role of specific immunohistochemical markers, such as STAT6 in differentiating a SFT from various other spindle cell tumors occurring in this location.
|
29257041 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Pathologists should be aware of the potential pitfall of the relatively frequent expression of PAX8 by SFT and STAT6 expression in liposarcoma.
|
28749793 |
2019 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive immunohistochemical stains for CD34 and STAT6 and the detection of NAB2-STAT6 fusion supported the diagnosis of dedifferentiated SFT in both cases.
|
29309807 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study confirms that the demonstration of a diffuse and strong STAT6 nuclear staining is very helpful in distinguishing solitary fibrous tumor from other spindle cell mimics arising in the breast.
|
30072169 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ninety per cent of SFTs showed nuclear expression of STAT6.
|
29106748 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Histologic blocks and available formalin-fixed smears of FNA specimens from SFTs were investigated for STAT6 immunoreactivity using a monoclonal antibody.
|
28914981 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Most notable classification changes include: adding 'hybrid nerve sheath tumours' to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells.
|
28295484 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
The other one was a spindle-cell de novo dedifferentiated SFT with heterogeneous nuclear and cytoplasmic STAT6 staining, which could only be correctly diagnosed after molecular analysis with demonstration of a NAB2-STAT6 gene fusion.
|
28968297 |
2018 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, an intrachromosomal gene fusion between NAB2 and STAT6 was identified as the defining driving genetic event of SFT and different fusion types correlated with tumor histology and behavior.
|
27292373 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
STAT6 immunostaining is useful for distinguishing malignant SFTs from other neoplasms.
|
28494796 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, most SFTs (30/33) (90.9%) displayed moderate to strong immunostaining for STAT6, including 3+ and 4+ immunostaining patterns in 27/33 (81.8%) tumors.
|
28869107 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In only 1 SFT case with weak and focal nuclear STAT6 immunostaining signal, STAT6 expression was rated discordant (observer 1: STAT6-negative, observers 2 and 3: STAT6-positive).
|
28128724 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of the new fusion gene, NAB2-STAT6, as an alternative tool specifically confirmed the diagnosis of SFT.
|
29310366 |
2017 |
|
Solitary fibrous tumor
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To date, nuclear STAT6 expression has not been reported in solitary fibrous tumour of the tongue.
|
28683839 |
2017 |