AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 GeneticVariation phenotype BEFREE For esophageal cancer, the AurkA Phe31-Ile polymorphism has previously been associated with tumor progression. 29560108 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 Biomarker phenotype BEFREE We recently found that aurora kinase A (AURKA) drives 20q gain-associated tumour progression and is associated with disease recurrence. 24104968 2013
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 AlteredExpression phenotype BEFREE AURKA overexpression is significantly associated with neoplastic transformation in several tumors and deregulated Aurora Kinases expression leads to chromosome instability, thus contributing to cancer progression. 21718475 2011
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 AlteredExpression phenotype BEFREE STK15 copy number is amplified in 12% of OSCCs and nuclear STK15 protein expression increases with tumour progression. 20597069 2010
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 Biomarker phenotype BEFREE Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression. 20929925 2010
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 AlteredExpression phenotype BEFREE Kaplan-Meier survival analysis revealed an increased risk of tumor progression for patients with Ta tumors (n = 62) and high STK15 expression (log-rank p = 0.04). 17465238 2007
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 AlteredExpression phenotype BEFREE We conclude that the up-regulation of AURKA mRNA may play a critical role in the tumor progression of HNSCC and provides useful information as a prognostic factor for HNSCC patients. 16951231 2006
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.080 AlteredExpression phenotype BEFREE Overall our results suggest that overexpression of Aurora-A/STK15 in bladder tumor cells contributes to tumor progression by promoting chromosomal instability leading to aneuploidy. 15547700 2004