AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Disease: Endometrial Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 GeneticVariation disease BEFREE Furthermore, we demonstrate that CRISPR-edited FBXW7-mutant ARK1 serous EC cells exhibit increased sensitivity to SI-2 (a SRC inhibitor) and dinaciclib (a cyclin dependent kinase (CDK) inhibitor) compared to parental ARK1 cells. 29963728 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 Biomarker disease BEFREE In vitro, genetic silencing of AXL inhibited migration and invasion but had no effect on proliferation of ARK1 endometrial cancer cells. 27764792 2016
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.030 Biomarker disease BEFREE We confirmed this result in an independent series of ECs included in a tissue microarray in which breast and ovarian cancer samples showed an incidence of STK15 amplification of 15 and 18%, respectively (P <or= 0.001). 14522886 2003