SIGNIFICANCE: Dephosphorylation of FZR1 by PRL-3 facilitates the activity of APC/C<sup>FZR1</sup> by destabilizing AURKA, thus influencing aggressive characteristics and overall progression of colorectal cancer.
In multivariate analysis, AURKA was associated with cyclin D1 expression (P = .010) and inversely with PIK3CA mutation (P=.014), fatty acid synthase expression (P=.028), and family history of colorectal cancer (P = .050), but not with sex, age, body mass index, tumor location, stage, CIMP, MSI, KRAS, BRAF, BMI, LINE-1 hypomethylation, p53, p21, beta-catenin, or cyclooxygenase 2.