Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca<sup>2+</sup> channel axis and contribute to bronchial hyperresponsiveness in asthma.
|
28754608 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly to other asthma-associated allergens, Alternaria secretes a serine-like trypsin protease(s) that is thought to act through the G protein-coupled receptor protease-activated receptor-2 (PAR<sub>2</sub>) to induce asthma symptoms.
|
30335499 |
2018 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vivo, an asthma animal model was established and the expression and distribution of BRS-3 were analyzed by immunocytochemistry.
|
29393253 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GPR35 is a poorly characterized G protein-coupled receptor (GPCR) that has been suggested as a potential therapeutic target for the treatment of diabetes, hypertension and asthma.
|
21392828 |
2011 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The G protein-coupled receptor neuropeptide S receptor 1 (NPSR1) and its ligand neuropeptide S (NPS) form a signaling system mainly implicated in susceptibility to asthma and inflammatory disorders in humans and regulation of anxiety and arousal in rodents.
|
20705147 |
2010 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Samples were analyzed for S100A7, S100A8, S100A9, SLC9A3R1, G-protein-coupled receptor for asthma, and serine protease inhibitor kazal type 5 (SPINK5) by quantitative real-time polymerase chain reaction.
|
18588753 |
2008 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GPCR genes implicated in asthma endophenotypes include variants of the cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled receptor associated with asthma (GPRA).
|
17154652 |
2006 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of GPRA, a novel G protein-coupled receptor related to asthma.
|
15947423 |
2005 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population.
|
15764725 |
2005 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies involving EPI-2010, a respirable antisense oligonucleotide (RASON), targeting the adenosine A(1) receptor, a G-protein-coupled-receptor (GPCR) that plays an important role in the aetiology of asthma, demonstrate that ASON therapeutics can be delivered directly to the lung as an aerosol.
|
11728229 |
2001 |