BRS3, bombesin receptor subtype 3, 680

N. diseases: 261; N. variants: 1
Disease: Obesity ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. 31002796 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Since 5-HT2CR is a class A G protein-coupled receptor (GPCR), drug discovery efforts have traditionally pursued the activation of the receptor through synthetic ligands with agonists proposed for the treatment of obesity, substance use disorders and impulse control disorders while antagonists may add value for the treatment of anxiety, depression and schizophrenia. 31288724 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE Moreover, BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces; but neither mutation nor even polymorphism in the BRS-3-gene was found in OB or T2D patients. 29402494 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE Brs3 null mice have reduced resting metabolic rate and body temperature, increased food intake, and obesity. 29107299 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.100 GeneticVariation disease BEFREE The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with bone remodelling, nervous system excitability, vascular homeostasis as well as in several pathophysiological conditions including obesity and cancer. 25970609 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.100 AlteredExpression disease BEFREE The analysis of BRS-3 expression in the skeletal muscle of these patients revealed a marked decrease in the expression of BRS-3 at the mRNA (23.6 ± 1.3-fold downregulation, p<0.0001) and protein level (49 ± 7% decrease, p<0.05) compared to the normal patients (no obesity and diabetes). 25653074 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE There is now considerable literature demonstrating a link between inhibitory guanine nucleotide-binding protein (G protein) and G protein-coupled receptor (GPCR) signaling in insulin-responsive tissues and the pathogenesis of obesity and T2DM. 24946790 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE BRS-3 plays an important role in glucose metabolism, and could be use as a molecular target, and/or its ligand, as a therapeutic agent for obesity and diabetes treatments. 23291341 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE The melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor (GPCR) that is expressed in the central nervous system and has a role in regulating feeding behavior, obesity, energy homeostasis, male erectile response, and blood pressure. 20462274 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease BEFREE GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. 18037923 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.100 GeneticVariation disease BEFREE No mutation, nor polymorphism was found in the coding region of BRS-3, suggesting that mutation of this gene is not a major cause of obesity in humans. 10727011 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.100 GeneticVariation disease BEFREE Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice. 10903341 2000