Collectively, our results revealed that miR‑485‑5p played a pivotal tumor‑suppressing role in CRC through downregulation of cancer‑associated gene CD147, and may provide a better understanding of the pathogenesis in CRC and a new bio‑target for CRC therapy.
In conclusion, these results suggest that CD147 plays an important role in colorectal CSCs and might be regarded as a novel CSC-specific targeted strategy against colorectal cancer.
Expression of CD147 and MMP-11 were both correlated with CRC lymph node metastasis (P = 0.021 and P = 0.031, respectively), distant metastasis (P < 0.001 and P = 0.013, respectively) and TNM stage (P = 0.006 and P = 0.049, respectively).
In the present study, we investigated the feasibility of using adenovirus‑mediated siRNA targeting CD147 based on the IGF2 LOI system for targeted gene therapy of CRC.