|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
These substrates are either parts of important signalling cascades (EGF, betacellulin, TGF-beta) or chemical components of myelin (neurofascin-ankyrin) known to be compromised in schizophrenia.
|
20218926 |
2010 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
These substrates are either parts of important signalling cascades (EGF, betacellulin, TGF-beta) or chemical components of myelin (neurofascin-ankyrin) known to be compromised in schizophrenia.
|
20218926 |
2010 |
|
Erythropoietic Protoporphyria
|
0.300 |
Biomarker
|
disease |
CTD_human |
We observed that the expression of amphiregulin, betacellulin and epiregulin was significantly increased in young EPP mice when compared to aged-matched controls in all genetic backgrounds.
|
19267999 |
2009 |
|
Ferrochelatase deficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injury.
|
19267999 |
2009 |
|
Otitis Media
|
0.200 |
Biomarker
|
disease |
RGD |
Growth factors and their receptors in the middle ear mucosa during otitis media.
|
12148846 |
2002 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
|
30804561 |
2019 |
|
Nephrotic Syndrome
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome.
|
29903748 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results are consistent with previous studies in Caucasian populations and suggest that variants in the betacellulin gene do not play a major role in the development of T2DM in Caucasian populations.
|
17479438 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We were unable to confirm a role for nonsynonymous variants of betacellulin in the propensity to type 2 diabetes or to impaired insulin secretion.
|
16869959 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that genetic variations in the protein-coding region of the human BTC gene are unlikely to be a major contributor to development of type 2 diabetes.
|
15936459 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes.
|
16306376 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Further studies will be needed to understand the different roles that betacellulin polymorphisms play in susceptibility to type 2 diabetes in Caucasians and African Americans.
|
15793259 |
2005 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Overexpression of betacellulin is found in a variety of cancers and is associated with reduced survival.
|
31654720 |
2020 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
EGFR and its ligands epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), betacellulin (BTC), amphiregulin (AREG) and transforming growth factor α (TGF-α) have potential applications as prognostic or predictive serological biomarkers in cancer.
|
31323001 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In vitro, the immunofluorescence staining and cell survival assays indicated that BTC NPs could re-educate 87% of the M2-like RAW264.7 macrophages stimulated by apoptotic tumor cell secretion and significantly inhibit the liver tumor cell proliferation.
|
31528908 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP).<b>Methods:</b> We used Cox proportional hazards regressions models to estimate HRs and 95% confidence intervals for associations between FHC (any, first-degree, in female relative, in male relative, relative with gastrointestinal cancer, and relative with hormonally related cancer) and BTC risk by anatomic site within the biliary tract, adjusting for sex and race/ethnicity.
|
29339358 |
2018 |
|
insulinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results revealed that 4-MC induces apoptosis and decreases insulin secretion by reducing BTC and inhibin beta-A in insulinoma INS-1 cells.
|
29473434 |
2018 |
|
insulinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Betacellulin was initially detected as a growth-promoting factor in the conditioned medium of a mouse pancreatic β-cell tumor cell line.
|
24440602 |
2014 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Among EGFR ligands, heparin-binding EGF-like growth factor, TGF-α and Betacellulin (BTC) are produced in the tumor microenvironment of FDC-S at RNA level.
|
23888072 |
2013 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Increased expression of BTC protein was observed in 31 (61%) of 51 HCC specimens, and the level of tumor growth factor-alpha protein was higher in 17 (33%) of 51 HCC specimens than in nonmalignant hepatocytes.
|
16949929 |
2006 |
|
insulinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Betacellulin: a mitogen from pancreatic beta cell tumors.
|
8456283 |
1993 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Neutralizing antibody against BTC abrogated activation of both EGFR and NF-ᴋB in response to inhibition of STAT3; with combinatorial blockade of STAT3 and BTC inducing apoptosis in glioblastoma cells.
|
31678994 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
EGFR and its ligands epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), betacellulin (BTC), amphiregulin (AREG) and transforming growth factor α (TGF-α) have potential applications as prognostic or predictive serological biomarkers in cancer.
|
31323001 |
2019 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Neutralizing antibody against BTC abrogated activation of both EGFR and NF-ᴋB in response to inhibition of STAT3; with combinatorial blockade of STAT3 and BTC inducing apoptosis in glioblastoma cells.
|
31678994 |
2019 |