SYK, spleen associated tyrosine kinase, 6850

N. diseases: 229; N. variants: 7
Disease: Hematologic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.040 AlteredExpression group BEFREE Inhibition of SYK activity has been explored as a therapeutic option in several allergic disorders, autoimmune diseases, and hematological malignancies. 29925062 2018
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.040 Biomarker group BEFREE Entospletinib is a selective inhibitor of SYK, which is currently being evaluated in phase II clinical trials for hematological malignancies. 29719615 2018
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.040 Biomarker group BEFREE Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. 24525236 2014
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.040 Biomarker group BEFREE The nonreceptor tyrosine kinase SYK has recently received a good deal of attention as a critical oncogene in various hematologic malignancies. 20439538 2010