|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnosis of primary renal synovial sarcoma requires histopathology and the confirmation of SYT-SSX gene fusion using molecular techniques.
|
31367627 |
2019 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization performed on the cell block demonstrated the presence of SYT (18q11) translocation, supporting the diagnosis of synovial sarcoma.
|
31173483 |
2019 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A transbronchial biopsy was performed, and immunohistochemical results as well as detection of SYT-SSX1 (SYnovial sarcoma Translocation-Synovial Sarcoma X chromosome breakpoint) transcripts resulted in a diagnosis of synovial sarcoma.
|
29455826 |
2018 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma (SS) is characterized by a tumour specific chromosomal translocation t(X;18) (p11;q11) which results in the formation of SYT-SSX1 fusion protein.
|
30219714 |
2018 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma (SS) is genetically characterized by chromosomal translocation, which generates <i>SYT-SSX</i> fusion transcripts.
|
29491688 |
2018 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is an aggressive sarcoma with specific reciprocal chromosomal translocation of SS18 (also known as SYT) and SSX genes.
|
27362474 |
2018 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is associated with a unique translocation, resulting in an SYT-SSX fusion gene.
|
27697479 |
2017 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion gene SYT-SSX may play a critical role in the molecular pathological of SS.
|
28498445 |
2017 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prognostic impact of SYT-SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials.
|
27621063 |
2017 |
|
Adult Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS).
|
26905812 |
2016 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence In Situ Hybridization (FISH) analysis showed a rearrangement of the synaptotagmin (SYT) gene, confirming the diagnosis of SS.
|
27118264 |
2016 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ultimately, an immunohistochemical stain for TLE-1 demonstrated diffusely strong nuclear positivity and molecular studies showed the presence of the t(X; 18) SYT/SSX1 translocation confirming the diagnosis of SS.
|
24436244 |
2014 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma.
|
24966982 |
2014 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although precise function of SYT-SSX remains to be investigated, accumulating evidences suggest its role in gene regulation via epigenetic mechanisms, and the product of SYT-SSX target genes may serve as biomarkers of SS.
|
23313505 |
2013 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
|
24228088 |
2013 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2.
|
21996728 |
2012 |
|
Adult Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2.
|
22594313 |
2012 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RT-PCR detection of SYT-SSX fusion transcripts played a key role in establishing the diagnosis of synovial sarcoma of the cauda equina.
|
22098598 |
2012 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increase of NCOA3 is essential for SYT-SSX1-mediated synovial sarcoma formation.
|
21454665 |
2011 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study may be valuable for understanding the pathogenic role and molecular mechanism of the fusion gene SYT-SSX in synovial sarcoma through the proposed genome-wide approach.
|
21234732 |
2011 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearranged SYT was successfully detected in all SSs but not in any ES/PNETs.
|
20660338 |
2010 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel SYT-SSX fusion transcript variants in synovial sarcoma.
|
19837269 |
2009 |
|
Adult Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prospectively, FNAs positive for the SYT-SSX fusion transcript by RT-PCR (n = 6) and, retrospectively, cases proven on histopathology and immunohistochemistry (ICC; positivity for vimentin and epithelial membrane antigen [EMA]/cytokeratin) as SS (n = 10) were included in the study.
|
19267417 |
2009 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma.
|
19385976 |
2009 |
|
Adult Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1.
|
19337376 |
2009 |