|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the effects of a neurokinin 1 receptor (NK1R) antagonist (WIN62577) on the migration of airway smooth muscle cells (ASMCs) and the expression of NK1R and alpha-tubulin in airway remodelling using young rats with asthma.
|
30233858 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results in humans with and without eosinophilic asthma showed that airway innervation and substance P expression were increased in moderate persistent asthmatics compared to mild intermittent asthmatics and healthy subjects.
|
30185653 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TAC1 had the highest sputum eosinophilia and exhaled nitric oxide fraction, and was restricted to severe asthma with oral corticosteroid dependency, frequent exacerbations and severe airflow obstruction.
|
28179442 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since tachykinins appear to be involved in the pathogenesis of allergic asthma, we investigated a possible association between 28 single nucleotide polymorphisms of the tachykinin genes TAC1, TAC3 and TAC4, and asthma susceptibility.
|
20580442 |
2010 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
When patients with acute asthma exacerbation were followed-up till remission, sputum NKA levels decreased significantly, but they remained significantly higher than controls.
|
18507649 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, NKA may be a target for new asthma therapy.
|
18507649 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the role of cysteinyl leukotrienes in neurokinin A-induced bronchoconstriction, we performed a randomised, double-blind, cross-over, placebo controlled trial in 12 patients with mild to moderate asthma.
|
17611132 |
2008 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evidence suggested LIF is related to the higher expression of neurokinin-1 receptor (NK-1R) in asthma.
|
17392578 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Substance P and neurokinin A are regulatory peptides of the tachykinin family that influence many aspects of human airway function in health and diseases such as bronchial asthma or chronic obstructive pulmonary disease (COPD).
|
15544859 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we investigated if SP boosts migration and cytotoxicity of natural killer cells, thus providing a further link between "innate immunity" and neurogenic inflammatory processes like asthma bronchiale.
|
14599723 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The purpose of the present study was to investigate the changes of NKA in plasma of asthmatic children and possible relationship between sensory neuropeptides and asthma in children.
|
14749007 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the past three years, work has entered the clinic and selective or dual-selective NK1/NK2 receptor antagonists appear to have the potential to affect the different aspects of asthma and COPD.
|
11712745 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin-converting enzyme (ACE) is expressed at high levels in the lungs and plays a role in the metabolism of angiotensin II, bradykinin, and substance P, all of which are potentially involved in the pathogenesis of asthma.
|
11030378 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin-converting enzyme (ACE) inactivates bradykinin, substance P and neurokinin A, which are believed to play important roles in the pathogenesis of asthma, especially in neurogenic inflammation.
|
10197222 |
1998 |