|
Constipation
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with the constipation model group, the mulberry-treated groups showed decreased aquaporin gene expression (Aqp3, Aqp4, Aqp8 and Aqp9), decreased serum levels of inhibitory neurotransmitters (nitric oxide and vasoactive intestinal peptide) (P < 0.05), and increased serum levels of excitability neurotransmitters (acetyl choline, substance P, and motilin).
|
30785176 |
2019 |
|
Constipation
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
AABP significantly increased the levels of gastrin (Gas), motilin (MTL), substance P (SP), 5-hydroxytryptamine (5-HT) and vasoactive intestinal peptide (VIP), and decreased the NO content of loperamide-induced rats to ameliorate constipation in the rats.
|
31102614 |
2019 |
|
Constipation
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The plasma concentrations of 5-HT in Group T was lower than Group C at T<sub>1</sub> (348.54 ± 138.49 vs. 418.69 ± 124.68, P = 0.03), T<sub>2</sub> (324.28 ± 112.73 vs. 398.52 ± 114.53, P < 0.01), T<sub>4</sub> (309.64 ± 129.09 vs. 388.46 ± 115.36, P = 0.04) postoperatively and concentrations of SP at T<sub>1</sub> (59.38 ± 24.68 vs. 78.93 ± 26.32, P < 0.01), T<sub>2</sub> (49.36 ± 25.55 vs. 66.49 ± 23.57, P = 0.02), T<sub>3</sub> (42.19 ± 24.36 vs. 64.15 ± 28.16, P = 0.04), T<sub>4</sub> (39.26 ± 19.88 vs. 54.64 ± 20.62, P = 0.02) postoperatively were also lower than Group C. Meanwhile, the occurrences of vertigo (6.7 vs. 18.3%, P < 0.01), nausea and vomiting (11.7 vs. 21.7%, P < 0.01), constipation (10.0 vs. 20.0%, P = 0.03) in Group T were also lower.
|
29557487 |
2019 |
|
Constipation
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The results demonstrated that UKP significantly increased feces condition (fecal output and dejecta moisture content, gut transit (the intestinal propulsion rates) and substance P (SP) levels in portal vein plasma, and it decreased the whole gut transit time and mucinogen granules secreted by goblet cell in constipated mice.
|
31652679 |
2019 |
|
Constipation
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
LP-YS3 also elevated motilin (MTL), endothelin (ET), acetylcholinesterase (AChE), substance P (SP), and VIP serum levels and reduced somatostatin (SS) levels in constipated mice.
|
29757072 |
2018 |
|
Constipation
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
To gain insight into the key role of intestinal microbiota in constipation and metabolic differences caused by isoflavones deficiency, we observed a significant decrease in fecal pellet numbers, fecal water content, intestinal transit rate together with the serum concentrations of substance P (SP) and vasoactive intestinal peptide (VIP) in NISO group, compared with those in the ISO group.
|
30564225 |
2018 |
|
Constipation
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, UDO, which can be easily obtained through milling to a satisfactory particle size, exhibited obvious laxative effect in diphenoxylate-induced constipated mice, and the mechanism might be associated with elevated levels of AChE, Gas, MTL, SP, and reduced production of SS.
|
28146409 |
2017 |
|
Constipation
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation.
|
19164461 |
2009 |
|
Constipation
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Larger numbers of patients need to be studied to investigate whether low SP is primarily associated with the constipation or RET mutation and if it is a common feature of MEN 2B.
|
16481266 |
2006 |