|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Dipeptidyl peptidase-4 inhibitor (DPP-4-Is), a kind of drug used for the treatment of diabetes, is considered to prevent the degradation of substance P that suppresses the occurrence of dysphagia.
|
31822955 |
2020 |
|
Diabetes Mellitus
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Compared with the diabetes mellitus patients, level of serum cystatin C was higher, and level of substance P peripheral blood was lower in diabetes mellitus patients complicated with hypertension.
|
30116366 |
2018 |
|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Therefore, this paper analysed changes in substance P- (SP-), calcitonin gene-related peptide- (CGRP-), and leu5-enkephalin- (L-ENK-) like immunoreactivity (LI) in enteric stomach neurons caused by chemically induced diabetes in a porcine model.
|
30140706 |
2018 |
|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Findings in this study indicated the lack of SP might be a possible indicator for the initial of diabetes.
|
30455626 |
2018 |
|
Diabetes Mellitus
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Multiple logistic regression analyses showed an association between 30-day mortality and serum SP levels at days 1, 4, and 8 (<i>p</i> < 0.001) controlling for SOFA score, diabetes mellitus, age, and lactic acid levels.
|
28714876 |
2017 |
|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Therefore, systemic treatment with SP may be a promising therapeutic strategy for treating diabetes in patients with loss of functional β-cells.
|
28754588 |
2017 |
|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Substance P concentrations were significantly higher in the tears of the control group compared to participants with diabetes (4150 ± 4752 and 1473 ± 1671 pg/mL, respectively, P = .047).
|
28650386 |
2017 |
|
Diabetes Mellitus
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Indeed, DHT counteracted the effect of diabetes on the mechanical nociceptive threshold, pre- and post-synaptic components, glutamate release, astrocyte immunoreactivity, and expression of interleukin-1β (IL1β), while 3α-diol was effective on tactile allodynia threshold, glutamate release, astrocyte immunoreactivity and the expression of substance P, toll-like receptor 4, tumor necrosis factor-α, transforming growth factor β-1, IL1β, and translocator protein.
|
24424289 |
2014 |
|
Diabetes Mellitus
|
0.090 |
Biomarker
|
group |
BEFREE |
Prolonged treatment with Chembridge-5861528 reduced the DM-induced attenuation of the cutaneous axon reflex and loss of substance P-like immunoreactive nerve fibers.
|
22133672 |
2012 |