|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to pathomechanisms of dry skin observed in SS, we recently reported that reduced sweating function and dry skin seen in atopic dermatitis (AD) are mediated by histamine or substance P, those are usually restored to normal levels after improvement of the dermatitis by topical corticosteroid ointment with or without oral anti-histamine.
|
30104151 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that topically administered SP may have potential as a medication for atopic dermatitis.
|
28833499 |
2018 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increased level of SP, in atopic dermatitis, induces the release of interferon (IFN)-γ, interleukin (IL)-4, tumor necrosis factor (TNF)-α, and IL-10 from the peripheral blood mononuclear leukocytes.
|
29713744 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
The experimental group designations and topical treatments were as follows: vehicle group (AD-VE); SP group (AD-SP); and SP with NK1R antagonist CP99994 (AD-SP-A) group.
|
29269174 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis.
|
29182791 |
2018 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, elevated expression of SP in patients with eczema and the ability of SP in induction of mast cell accumulation indicate strongly that SP is a potent proinflammatory mediator, which contributes to the pathogenesis of eczema.
|
28154998 |
2017 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The plasma SP level was 4.9-fold higher in patients with AD than in HC subjects.
|
28460633 |
2017 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TAC2 showed the highest sputum neutrophilia, serum C-reactive protein levels and prevalence of eczema.
|
28179442 |
2017 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mitochondrial translocation is also evident by transmission electron microscopy in skin mast cells from AD biopsies, in which gene expression of calcineurin, Drp1, and SP is higher than in normal skin.
|
21453958 |
2011 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is increasing evidence that neuropeptides such as a substance P, neurotrophins or beta-endorphin, an endogenous agonist for mu-opioid receptor, are involved in the pathogenesis of atopic dermatitis in which mental stress and scratching deteriorate the disease. mu-Opioid receptor, a G-protein-coupled receptor, can be downregulated and internalized by agonists and other factors in vitro.
|
15724090 |
2005 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that substance P modifies immune responses of atopic T cells to Der f by promoting proliferation and altering cytokine profiles, and thus modulates the clinical manifestations of atopic dermatitis.
|
9617438 |
1998 |