|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Migraine headaches are theorized to cause aura and symptoms via spreading cortical depression that ultimately results in substance P release, alterations in blood flow, and neurogenic inflammation.
|
31629154 |
2020 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We quantified Tacr1 (neurokinin-1 receptor gene) and Avp (vasopressin peptide gene) mRNA in brain regions involved in depression, addiction and social behavior.
|
28150369 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results show a significant upregulation of MAOA and TAC1 in the medial area frontopolaris which is a node in the limbic-cortical network and known to be susceptible for gray matter loss and behavioral dysfunction in patients with depression.
|
29478144 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Through activation of NK<sub>1</sub>R, substance P modulates a wide variety of physiological and disease processes including nociception, inflammation, and depression.
|
30538204 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We consider our findings to contribute to the neurobiological evidence on the association between SP and brain structural changes in depression, which may be related with the pathophysiology and treatment of MDD.
|
28852030 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
More recently, SP and the NK1R have gained attention for their role in complex psychiatric processes including stress, anxiety, and depression.
|
29056150 |
2017 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The study aimed at assessing the concentrations of ADMA, carbonyl groups, CAT and NKA in patients with varying levels of depression severity, PTSD, and depression concurrent with PTSD.
|
28554099 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Increasing evidence suggests that substance P (SP) neurokinin-1 (NK1) receptors are involved in stress and emotional responses, representing a potential target for the treatment of anxiety and depression in humans.
|
15845098 |
2005 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because of the possible antidepressant effects of SP antagonists, the influence of SP on both pathophysiology and mitigation of depression has been hypothesized.
|
15157992 |
2004 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In summary, much more research is needed to elucidate the role of SP in the pathogenesis of depression.
|
12692775 |
2003 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This review summarizes the pre-clinical evidence derived from pharmacological and transgenic animal studies that suggests an important role for the substance P/neurokinin 1 system in anxiety and depression.
|
12907922 |
2003 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The question is raised whether the present results may be of significance for understanding a possible role of substance P in depression.
|
10716242 |
1999 |