ADAM17, ADAM metallopeptidase domain 17, 6868

N. diseases: 316; N. variants: 11
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 Biomarker disease BEFREE Underlining the link between colon cancer and ADAM17, genetic intestinal cancer models in ADAM17-deficient mice show a reduced tumor burden. 31060243 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE We studied FHL2 and ADAM-17 expression in several colon cancer cell lines by immunocytochemistry and western blot. 28349819 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 Biomarker disease BEFREE TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production. 27837433 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 Biomarker disease BEFREE ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. 27489286 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. 27874952 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.060 AlteredExpression disease BEFREE In colon cancers, survivin expression positively correlated with the coexpression of PUMA (P < .001), TACE (P = .003), and MCL1 (P = .01), and trended toward an inverse correlation with BAX (P = .058). 21855041 2011