ADAM17, ADAM metallopeptidase domain 17, 6868

N. diseases: 316; N. variants: 11
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE Underlining the link between colon cancer and ADAM17, genetic intestinal cancer models in ADAM17-deficient mice show a reduced tumor burden. 31060243 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE We studied FHL2 and ADAM-17 expression in several colon cancer cell lines by immunocytochemistry and western blot. 28349819 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. 27489286 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 Biomarker disease BEFREE TLR4-mediated galectin-1 production triggers epithelial-mesenchymal transition in colon cancer cells through ADAM10- and ADAM17-associated lactate production. 27837433 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. 27874952 2016
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.060 AlteredExpression disease BEFREE In conclusion, this study is the first demonstration that ADAM17 is overexpressed in human primary colon carcinoma, whatever the tumour stage and differentiation and whatever the level of EGFR expression. 16041691 2005