TACR1, tachykinin receptor 1, 6869

N. diseases: 217; N. variants: 10
Disease: Addictive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 AlteredExpression phenotype BEFREE We quantified Tacr1 (neurokinin-1 receptor gene) and Avp (vasopressin peptide gene) mRNA in brain regions involved in depression, addiction and social behavior. 28150369 2018
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE Both NK1R and NFkB have been shown to play a functional role in complex behaviors including stress responsivity, depression, and addiction. 29486768 2018
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE Given promising clinical findings for the efficacy of NK1R antagonists on craving in alcoholics, along with recent data suggesting that a number of negative results from NK1R trials were likely due to insufficient receptor occupancy, the NK1R merits being revisited as a target for the development of novel pharmacotherapeutics for addiction. 29056150 2017