|
Squamous cell carcinoma of esophagus
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Compared to their expression in the adjacent normal epithelia, 12 proteins, including transgelin (TAGLN), were upregulated in ESCC tissues; 17 proteins, including proteasome activator 28-beta subunit (PA28β), were downregulated (p < 0.05).
|
29020885 |
2017 |
|
Endometriosis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation.
|
21763649 |
2011 |
|
Endometriosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.310 |
Biomarker
|
disease |
CTD_human |
Among these identified proteins, 33 proteins including keratin 17 (KRT17), biliverdin reductase B (BLVRB), proteasome activator subunit 1 (PSME1), manganese superoxide dismutase (MnSOD), high-mobility group box-1(HMGB1), heat shock protein 70 (HSP70), peroxiredoxin (PRDX1), keratin 13 (KRT13), and so on were overexpressed, and 14 proteins including cystatin B (CSTB), tropomyosin 2 (TPM2), annexin 1 (ANX1), transgelin (TAGLN), keratin 19 (KRT19), stratifin (SFN), and so on were down-expressed in ESCC.
|
21517111 |
2011 |
|
Malignant tumor of colon
|
0.310 |
Biomarker
|
disease |
CTD_human |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
15059925 |
2004 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
15059925 |
2004 |
|
Malignant tumor of colon
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We conclude that loss of transgelin gene expression may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development.
|
11773051 |
2002 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
BEFREE |
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.
|
11773051 |
2002 |
|
Colonic Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.
|
11773051 |
2002 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Keloid
|
0.300 |
Biomarker
|
disease |
CTD_human |
Comparative proteomic analysis between normal skin and keloid scar.
|
20128793 |
2010 |
|
Lipoidosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.
|
17175557 |
2007 |
|
Lipoidosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Improved toxicogenomic screening for drug-induced phospholipidosis using a multiplexed quantitative gene expression ArrayPlate assay.
|
16919414 |
2006 |
|
Lipoidosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
|
15342952 |
2005 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We identified potential novel upstream regulators (e.g., CNOT7, SPDEF, MITF, and PAX5) controlling distinct clusters of genes within the HPV-host cell network as well as distinct factors (e.g., CPPED1, LCP1, and TAGLN) with essential functions in cancer.
|
30918060 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By microarray, Q-RT-PCR and 3'UTR luciferase assay, TAGLN, an early marker of smooth muscle differentiation and tumor suppressor, was identified as a target gene of miR-1587, thus providing a direct target to study miR-1587 functions.
|
30290263 |
2019 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
TAGLN promoted cell colony formation and cell migration and invasion both in vitro and in vivo by inducing invadopodia formation and epithelial-mesenchymal transition, during which a significant correlation between TAGLN and Slug was observed.
|
31420300 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In vitro, TAGLN knockdown enhanced cell proliferation and invasion, while overexpression of TAGLN had the inverse effects in bladder carcinoma cells.
|
31591355 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
We identified potential novel upstream regulators (e.g., CNOT7, SPDEF, MITF, and PAX5) controlling distinct clusters of genes within the HPV-host cell network as well as distinct factors (e.g., CPPED1, LCP1, and TAGLN) with essential functions in cancer.
|
30918060 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Previous studies have suggested that transgelin expression is associated with cancer development and progression, but its specific role in colorectal cancer (CRC) remains controversial.
|
29416680 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TAGLN is an actin-binding protein family that comprises three isoforms with theorized roles in smooth muscle differentiation, tumour development, lymphocyte activation, and brain chemistry.
|
29615809 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transgelin-1 (SM22α) has been recognized as a smooth muscle marker and a tumor suppressor, but many details of the working mechanisms remain unclear.
|
30301526 |
2018 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |