To investigate the transport mechanism of <sup>18</sup>F-FPGLU, we conducted a series of competitive inhibition experiments on HCCSMCC-7721 cells in the absence or presence of Na<sup>+</sup> and various types of inhibitors.
Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer.
Invasion and wound healing assays showed that both TGS and PTGS of the heparanase gene could inhibit invasion and migration of hepatomaSMCC-7721 cells, especially the TGS group.
Here, we exchanged the constitutive promoter in the pEPI derivative pEPito by the tumor specific alpha fetoprotein (AFP) or the muscle specific smooth muscle 22 (SM22) promoter leading to specific transgene expression in AFP positive human hepatocellular carcinoma (HUH7) and in a SM22 positive cell line, respectively.