Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE The interest towards the therapeutic targeting of TAK1 is due to its identification as one of the main mediators of both chemoresistance and EMT in several types of tumors, and as the possible target for a subset of treatment-refractory colon cancers exhibiting mutated KRAS or activated WNT pathways. 29145973 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling. 27655129 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE These results support the hypothesis that thiol-mediated oxidative stress is causally related to TAK1-induced colon cancer cell killing. 26114584 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE Together, these findings identify TAK1 inhibition as a potential therapeutic strategy for a treatment-refractory subset of colon cancers exhibiting aberrant KRAS and Wnt pathway activation. 22341439 2012