|
Bare Lymphocyte Syndrome, Type I
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome.
|
10074494 |
1999 |
|
Bare Lymphocyte Syndrome, Type I
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Bare Lymphocyte Syndrome, Type I
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Malignant neoplasm of prostate
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the PSF1 expression correlated significantly with overall survival (hazard ratio (HR) 5.5; 95% confidence interval (CI) 2.17-15.8; P=0.003) and progression-free survival in 99 consecutive patients with prostate cancer.
|
25403418 |
2015 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We found significant associations between schizophrenia and TAP1 allele frequencies (P=9.95x10(-3), chi(2)=12.36) as well as TAPASIN allele frequencies (P=2.8x10(-2), chi(2)=5.3).
|
19217216 |
2009 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We found significant associations between schizophrenia and TAP1 allele frequencies (P=9.95x10(-3), chi(2)=12.36) as well as TAPASIN allele frequencies (P=2.8x10(-2), chi(2)=5.3).
|
19217216 |
2009 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TAP1 I333V gene polymorphism was significantly associated with increased T1DM risk.
|
24655325 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we have investigated the frequencies of TAP1 and TAP2 alleles in a group of 226 persons, living in La Reunion Island, consisting of 70 patients with insulin-dependent diabetes mellitus (IDDM) and most of their first degree relatives (i.e., 156 parents and full sibling subjects) and previously HLA DQB1, DQA1, and DRB1 genotyped.
|
15336779 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In order to determine the ethnic origin of the transporter associated with antigen processing 2 (TAP2) G allele, initially discovered by us in a group of type 1 diabetes (insulin-dependent diabetes mellitus) patients living on Reunion Island, HLA TAP2 typing was performed using the polymerase chain reaction-amplification refractory mutation system (PCR-ARMS) method in type 1 diabetes patients and unrelated healthy controls of three different ethnic groups (Caucasians, Indians and black Africans from Senegal and Mauritius).
|
12786999 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The TAP1 and TAP2 transporters, which mediate the translocation of antigenic peptides into the endoplasmic reticulum and whose genes are located in the HLA class II region, are potential candidates for conferrring predisposition to type I diabetes.
|
11916171 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, TNFa*12 appeared to provide additional risks to IDDM besides the DRB1*0301 haplotype, whereas TNFa*11 and TAP1*4 conferred an independent protective effect against IDDM.
|
10527399 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found that although no single TAP1 polymorphism was associated with IDDM, a genotypic combination of Ile/Val at codon 333 with Asp/Asp at codon 637 was found more frequently in subjects with IDDM (9.4%) compared to controls (1.2%; p = 0.025).
|
9129974 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To investigate the frequency of the transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) alleles and their role in the susceptibility to type 1 diabetes, in comparison with the well-known HLA-DQ alleles susceptibility, in Senegalese subjects.
|
9250458 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
TAP1*02011 (16% vs. 4% in controls, P = 0.001, RR = 5.0) and TAP2*0101 (96% vs. 69% in controls, P < 0.0001, RR = 10.6) showed a positive association with IDDM.
|
9226129 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sequencing of TAP1 fragments encompassing exon 7 gave rise to a DGGE band pattern exclusively observed in an IDDM patient and sequencing revealed a previously unidentified polymorphisms at codon 518 (GTC-->ATC, Val-->Ile).
|
9458110 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Likewise, haplotype DRB1*04 is characterized in 1b-IDDM patients by a lower frequency of alleles TAP1-C (4.0%) and TAP2-B (8.0%) than in 1a-IDDM patients (22.2% and 25.9%, respectively).
|
8988536 |
1996 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Because the recently discovered transporter associated with antigen processing (TAP) and large multifunctional protease (LMP) genes are encoded in the HLA class II region and are implicated in the processing of antigenic proteins for presentation by HLA class I molecules, they are additional candidates for a role in IDDM pathogenesis.
|
7903260 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.
|
7871524 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which are located in the class II HLA region, are HLA-linked diabetogenic genes, the association of TAP1, TAP2 and LMP2 genes with type 1 diabetes was analyzed in the Japanese population.
|
7911550 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.
|
8052140 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These data provide new limits for IDDM susceptibility to the 190-kb interval between TAP1 and HLA-DQB1.
|
8248212 |
1993 |