|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In both systems we consistently found that mice bearing tumors containing Tat11-TK cells displayed significantly retarded tumor growth and prolonged survival as compared with mice inoculated with cells expressing unmodified TK.
|
16390270 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LACP can enter tumor cells and release CP into the cytosol by laser-triggered thermo-effects of the AuNPs; the CP can enter nuclei by TAT guidance, enabling effective knock-outs of target gene (Plk-1) of tumor (melanoma) and inhibition of the tumor both in vitro and in vivo.
|
29282854 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, pancreatic adenocarcinoma allografts treated with intratumoral TAT-CTMP and systemic gemcitabine displayed a significantly smaller tumor burden while undergoing treatment than mice in control groups (p < 0.001).
|
19405118 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MMP2-overexpressing tumor microenvironment caused deprotection by removal of PEG, resulting in the decrease of particle size and exposure of KLAK and TAT, which enhanced tumor penetration, the entry of bioactive peptides into cells and subsequently the effective disruption of mitochondria.
|
29406549 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A 56% decrease in the proliferative index in tumors treated with the TATFLAGVHL-peptide versus control-peptide-treated mice was observed.
|
11280720 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Systemically administered TAT-N24 also significantly decreases growth of leukemia cell tumors in animal models.
|
22722333 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this paper, we constructed and identified the recombinant adeno-associated virus NT4-TAT-6 × His-VHLbeta and studied the antitumor effect of the adeno-associated virus on xenografted tumors of chicken embryo chorioallantoic membrane.
|
25091575 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, administration of MS-harboring TAT-TLK1B did not affect the sensitivity of tumors to radiation in a nude mouse xenograft tumor model.
|
31011632 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A plasmid coding for a specific cytotoxic fusion peptide, p14ARF-TAT, was evaluated in a xenograft mouse tumor model.
|
21246396 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On this basis, modification with TAT peptide (YGRKKRRQRRR) significantly improved tumor intracellular uptake, devoting to better curative effects and minimized side effects by reducing CDDP therapeutic doses.
|
30826059 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show that the expression of TAT is repressed in tumors suggesting that this gene could act as a tumor suppressor in breast cancer and could be used as a new biomarker.
|
31703592 |
2019 |