|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, when fused to the tat protein-transduction sequence and subsequently introduced into cells, the C2 peptides potently promoted the RhoGAP function in DLC1, leading to decreased RhoA activation and reduced tumor cell growth in soft agar and migration in response to growth factor stimulation.
|
31806702 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Following administration, <sup>D</sup> TRCD experiences prolonged circulation by masking the targeting effect of its TAT peptide and then achieves enhanced tumor cell uptake and improved translocation into the perinuclear region by reactivating the TAT targeting capability in tumor tissue.
|
31318147 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It was further passivated by thiolated poly(ethylene glycol)-tumor homing peptides (NGR and TAT) to improve its cancer tissue penetrating, and accurate targeting ability.
|
31847931 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, administration of MS-harboring TAT-TLK1B did not affect the sensitivity of tumors to radiation in a nude mouse xenograft tumor model.
|
31011632 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On this basis, modification with TAT peptide (YGRKKRRQRRR) significantly improved tumor intracellular uptake, devoting to better curative effects and minimized side effects by reducing CDDP therapeutic doses.
|
30826059 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results show that the expression of TAT is repressed in tumors suggesting that this gene could act as a tumor suppressor in breast cancer and could be used as a new biomarker.
|
31703592 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The co-administration of iRGD strengthened the permeability of kla-TAT peptide against A549 2D and 3D sphere model with the penetration improvement property of iRGD; more importantly, co-administration with iRGD dramatically enhanced the accumulation of kla-TAT peptide in tumor tissue on the xenograft mice model with the homing property of iRGD.
|
29722179 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combining the cell-internalizing property of TAT with the tumor-specific property of tumstatin7 may provide a useful adjunct to tumor therapy.
|
30522555 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The folic acid and TAT peptide dual-ligand liposome also demonstrated enhanced tumor penetration as observed using 3D tumor spheroid models.
|
29908938 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LACP can enter tumor cells and release CP into the cytosol by laser-triggered thermo-effects of the AuNPs; the CP can enter nuclei by TAT guidance, enabling effective knock-outs of target gene (Plk-1) of tumor (melanoma) and inhibition of the tumor both in vitro and in vivo.
|
29282854 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MMP2-overexpressing tumor microenvironment caused deprotection by removal of PEG, resulting in the decrease of particle size and exposure of KLAK and TAT, which enhanced tumor penetration, the entry of bioactive peptides into cells and subsequently the effective disruption of mitochondria.
|
29406549 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Herein, a polymeric nanoparticle with tumor acidity (pH<sub>e</sub>)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd<sup>3+</sup> is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT.
|
28437627 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor.
|
29045464 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Next, to investigate tumor growth delay after irradiation, HCT116 cell lines were selected and xenografted onto nude mice that were then treated with TAT-RasGAP<sub>317-326</sub> alone or in combination with radiation or cisplatin.
|
28323576 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CPP2 could more selectively penetrate CRC cells than TAT or R8 as well as effectively deliver the p16MIS to the tumor.
|
27485348 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously shown that a cell-permeable peptide derived from the p120 Ras GTPase-activating protein (RasGAP), called TAT-RasGAP317-326, bears anti-malignant activities in vitro and in vivo, such as inhibition of metastatic progression and tumor cell sensitization to cell death induced by various anti-cancer treatments.
|
27602963 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The targeted inhibition of Livin by the cell-permeable peptide (TAT-Lp15) in intracerebral glioblastoma-bearing mice demonstrated a synergistic suppression of tumor growth and increased the survival rate in standard-of-care treatment with radiation plus temozolomide.
|
25370472 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this paper, we constructed and identified the recombinant adeno-associated virus NT4-TAT-6 × His-VHLbeta and studied the antitumor effect of the adeno-associated virus on xenografted tumors of chicken embryo chorioallantoic membrane.
|
25091575 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This TAT-vault nanoparticle could be a valuable tool for improving the retention and penetration of therapeutic drugs at tumor sites.
|
22785558 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Systemically administered TAT-N24 also significantly decreases growth of leukemia cell tumors in animal models.
|
22722333 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, while tumor cell infectivity was severely reduced for Ad5 in the presence of fiber proteins, it was only marginally reduced for Tat-PTD-modified Ad5.
|
21957304 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A plasmid coding for a specific cytotoxic fusion peptide, p14ARF-TAT, was evaluated in a xenograft mouse tumor model.
|
21246396 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Introduction of the TAT gene into HCC cell lines could effectively inhibit colony formation in soft agar, foci formation, and tumor formation in nude mice.
|
20209601 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, pancreatic adenocarcinoma allografts treated with intratumoral TAT-CTMP and systemic gemcitabine displayed a significantly smaller tumor burden while undergoing treatment than mice in control groups (p < 0.001).
|
19405118 |
2009 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance.
|
18539355 |
2008 |