|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brachyury and chordoma: the chondroid-chordoid dilemma resolved?
|
16604512 |
2006 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide compelling evidence that chordomas derive from notochord and demonstrate that brachyury is a specific marker for the notochord and notochord-derived tumours.
|
16538613 |
2006 |
|
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Screening for mutations in brachyury (all coding exons and promoter), FGFRs 1-4 (previously reported mutations), KRAS (codons 12, 13, 51, 61) and BRAF (exons 11 and 15) failed to show any genetic alterations in 23 chordomas.
|
19407855 |
2009 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All 10 typical and 4 poorly differentiated chordomas expressed brachyury; all 8 AT/RTs were brachyury immunonegative.
|
21057957 |
2010 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The demonstration of gains of copy number of both T (brachyury homologue) and EGFR (epidermal growth factor receptor) genes in chordoma, as well as of their role in promoting cell proliferation, offers a strong preclinical rationale for exploring the inhibition of their products as a credible therapeutic strategy.
|
21394718 |
2011 |
|
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent genomic investigation of chordomas has identified T (Brachyury) gene duplication as a major susceptibility mutation in familial chordomas.
|
21699479 |
2011 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.
|
22847733 |
2012 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brachyury is useful in separating parachordoma/myoepithelioma from chordoma.
|
23097005 |
2012 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining and western blot analysis confirmed the presence of brachyury, a recently described marker of chordomas, in the tumor from the patient and each of the xenografts.
|
22283186 |
2012 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of brachyury in chordoma is necessary to maintain cell proliferation in chordoma cell lines, indicating that in chordoma it might be a master regulator of oncogenesis.
|
22952146 |
2012 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cells are brachyury-positive and have the characteristics of chordoma.
|
22002331 |
2012 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Brachyury expression in chordoma tissues from 78 chordoma patients was analyzed by immunohistochemical staining of tissue microarray.
|
24086644 |
2013 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cells were cultured for more than 30 passages and the expression of the chordoma cell marker brachyury was monitored using both immunohistochemistry and Western blot.
|
23814489 |
2013 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Known for decades as a main regulator of notochord formation, Brachyury has recently gained interest as a biomarker and causative agent of chordoma, and therefore as a promising therapeutic target.
|
23662285 |
2013 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The brachyury gene is believed to be one of the key genes involved in the pathogenesis of chordoma, a rare primary bone tumor originating along the spinal column or at the base of the skull.
|
24232574 |
2013 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent advances in the understanding of the molecular events that contribute to the development of chordomas are promising; the most novel finding being the identification of brachyury in the disease process.
|
25193090 |
2014 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The second case was a quickly fatal clival tumor in a 2-year-old boy: This tumor was morphologically undifferentiated and raises the problem of differential diagnosis between an MRT, a malignant myoepithelial tumor, or an undifferentiated chordoma due to the location and the expression of brachyury.
|
25053104 |
2014 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast growth factor (FGF), a regulator of brachyury expression in normal tissue, may also play an important role in chordoma pathophysiology.
|
24445144 |
2014 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests that brachyury is a crucial molecular driver in the initiation and propagation of chordoma.
|
29360338 |
2016 |
|
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All 8 cases were positive for brachyury, whereas there was no nuclear SMARCB1/INI1 expression in 4 of the 8 cases, including the poorly differentiated chordoma.
|
27635948 |
2017 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To call attention to this association, we present a brachyury-immunopositive chordoma occurring in the skull base of a 2-month-old male infant who was later realized to have metastases to the subcutaneous tissues and lungs, as well as rhabdomyoma of the heart and renal cysts/angiomyolipomas, that is, characteristic features of the TS complex.
|
28498973 |
2017 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that brachyury is a crucial regulator of stemness in chordoma and in more common aggressive cancers.
|
29020634 |
2017 |
|
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.
|
29026114 |
2017 |
|
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chor-IN-1 displays genomic identity to the tumor of origin and has morphological features, growth characteristics and chromosomal abnormalities typical of chordoma, with expression of brachyury and other relevant biomarkers.
|
28835717 |
2017 |
|
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the single nucleotide polymorphism (SNP) rs2305089 in the T (brachyury) gene was strongly associated with sporadic chordoma development, but its clinical utility is undetermined.
|
27663388 |
2017 |