Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, Brachyury, or T-protein, has been shown to be an early mutational event in chordoma evolution.
|
31504814 |
2020 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these data demonstrate small-molecule targeting of brachyury transcription factor addiction in chordoma, identify a mechanism of T gene regulation that underlies this therapeutic strategy, and provide a blueprint for applying systematic genetic and chemical screening approaches to discover vulnerabilities in genomically quiet cancers.
|
30664779 |
2019 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results provide the first <i>in vivo</i> evidence against a tumor-initiating potential of Brachyury in the notochord, and imply activated RTK signaling as a possible initiating event in chordoma.
|
31221659 |
2019 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the characteristics of vascular and tumor cells in chordoma, we first analyzed the expression of VEGF receptor (VEGFR) 1, VEGFR2, CD34, and Brachyury in a cell line and 54 tumor tissues.
|
31240525 |
2019 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The GSK3β inhibitor (AR) decreased brachyury expression and suppressed the growth and survival of the chordoma cells, possibly via regulation of the Wnt/β-catenin signaling pathway.
|
31819479 |
2019 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The embryonic transcription factor Brachyury confers chordoma chemoresistance via upregulating CA9.
|
29636883 |
2018 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of PI3K/Akt pathway genes was upregulated in Brachyury high-expression tumors, and suppression of PI3K signaling led to reduced Brachyury expression and inhibition of cell growth in the U-CH2 chordoma cell line.
|
28753115 |
2018 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We then investigated the molecular mechanisms behind the responses observed and found that the antiproliferative IC<sub>50</sub>s correlate with the unique ability of afatinib to promote degradation of EGFR and brachyury, an embryonic transcription factor considered a key driver of chordoma.
|
29237806 |
2018 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Axial and extra-axial chordoma exhibits complete morphologic and immunophenotypic (expression of brachyury) overlap.
|
29560513 |
2018 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All 8 cases were positive for brachyury, whereas there was no nuclear SMARCB1/INI1 expression in 4 of the 8 cases, including the poorly differentiated chordoma.
|
27635948 |
2017 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To call attention to this association, we present a brachyury-immunopositive chordoma occurring in the skull base of a 2-month-old male infant who was later realized to have metastases to the subcutaneous tissues and lungs, as well as rhabdomyoma of the heart and renal cysts/angiomyolipomas, that is, characteristic features of the TS complex.
|
28498973 |
2017 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that brachyury is a crucial regulator of stemness in chordoma and in more common aggressive cancers.
|
29020634 |
2017 |
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.
|
29026114 |
2017 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chor-IN-1 displays genomic identity to the tumor of origin and has morphological features, growth characteristics and chromosomal abnormalities typical of chordoma, with expression of brachyury and other relevant biomarkers.
|
28835717 |
2017 |
Chordoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the single nucleotide polymorphism (SNP) rs2305089 in the T (brachyury) gene was strongly associated with sporadic chordoma development, but its clinical utility is undetermined.
|
27663388 |
2017 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests that brachyury is a crucial molecular driver in the initiation and propagation of chordoma.
|
29360338 |
2016 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent advances in the understanding of the molecular events that contribute to the development of chordomas are promising; the most novel finding being the identification of brachyury in the disease process.
|
25193090 |
2014 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The second case was a quickly fatal clival tumor in a 2-year-old boy: This tumor was morphologically undifferentiated and raises the problem of differential diagnosis between an MRT, a malignant myoepithelial tumor, or an undifferentiated chordoma due to the location and the expression of brachyury.
|
25053104 |
2014 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast growth factor (FGF), a regulator of brachyury expression in normal tissue, may also play an important role in chordoma pathophysiology.
|
24445144 |
2014 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Brachyury expression in chordoma tissues from 78 chordoma patients was analyzed by immunohistochemical staining of tissue microarray.
|
24086644 |
2013 |
Chordoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cells were cultured for more than 30 passages and the expression of the chordoma cell marker brachyury was monitored using both immunohistochemistry and Western blot.
|
23814489 |
2013 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Known for decades as a main regulator of notochord formation, Brachyury has recently gained interest as a biomarker and causative agent of chordoma, and therefore as a promising therapeutic target.
|
23662285 |
2013 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The brachyury gene is believed to be one of the key genes involved in the pathogenesis of chordoma, a rare primary bone tumor originating along the spinal column or at the base of the skull.
|
24232574 |
2013 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.
|
22847733 |
2012 |
Chordoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brachyury is useful in separating parachordoma/myoepithelioma from chordoma.
|
23097005 |
2012 |