Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral Tax protein plays a major role in ATL development.
|
28833639 |
2017 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, our findings suggest that both HBZ and Tax1 are negative regulators of immediate early IFN-β innate immune responses, while HBZ but not Tax1 positively regulates the induction of IFN-α and downstream IFN-α signaling.<b>IMPORTANCE</b> Type I interferons are powerful antiviral cytokines and are used extensively in the treatment of HTLV-1-induced adult T cell leukemia (ATL).
|
28768861 |
2017 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The viral regulatory protein Tax1 plays a pivotal role in T-cell transformation and ATL development.
|
23616667 |
2013 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic changes in the tax gene in ATL cells were reported in about 10% of ATL cases.
|
20463074 |
2010 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At the incipient stages of the development of adult T-cell leukemia, T-cells infected with human T-cell leukemia virus type 1 (HTLV-1) suffer disregulation in cell growth caused by aberrant expression of host genes by the HTLV-1 transactivator protein Tax (Tax1).
|
19617351 |
2009 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pin1 is highly expressed in adult T-cell leukemia (ATL) cells expressing Tax protein and forced expression of Pin1 in turn increases the Tax protein expression.
|
19338781 |
2009 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retroviral Tax proteins from human T cell leukemia virus type 1 and type 2 (HTLV-1 and -2) are capable of activating IKK, yet only HTLV-1 infection causes T cell leukemia, which correlates with persistent activation of NF-kappaB induced by Tax1.
|
19129196 |
2009 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pathogenic potential of human T-cell leukemia virus type 1 (HTLV-1) Tax protein is partly ascribed to its capacity to constitutively activate NF-kappaB factors because constitutive activity of these factors play an important role in the pathophysiology of adult T-cell leukemia (ATL) and tropical spastic paraparesis-HTLV-1 associated myelopathy (TSP-HAM).
|
18425496 |
2008 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, tax gene expression in ATL cells is disrupted by several mechanisms, including genetic changes in the tax gene and DNA methylation/deletion of the 5' long terminal repeat (LTR).
|
16407133 |
2006 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The premature stop codon in tax gene existed in many non-ATL HTLV-I carriers as a minor population but not in the commonest HTLV-I sequence of the individual.
|
16052518 |
2006 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HTLV Tax protein is crucial for viral replication and for initiating malignant transformation leading to the development of adult T-cell leukemia.
|
16155604 |
2005 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Tax-targeted vaccines may be effective for prophylaxis of ATL in a high-risk group, and also for therapy of ATL in at least half the cases.
|
15904464 |
2005 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The viral Tax protein is considered to play a central role in the process leading to ATL.
|
15310405 |
2004 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the development of both TSP/HAM and ATL seems to depend on the viral Tax protein, we describe a possible system for anti Tax gene-therapy approach based on a negative transdominant mutant Tax gene.
|
12469209 |
2003 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
First, a premature stop codon in the 5' half of the tax gene that looses transactivation activity on the viral enhancer was observed in 3 patients with acute and 1 patient with chronic ATL.
|
11159527 |
2001 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
HTLV-1 proviruses encoding non-functional TAX in adult T-cell leukemia.
|
11724264 |
2001 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human T-cell leukemia virus type 1 Tax protein transforms human T lymphocytes, which can lead to the development of adult T-cell leukemia.
|
9528808 |
1998 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results strongly suggest that HTLV-I tax gene may transactivate IL-6 gene through kappa B site in HTLV-I-positive T-cell lines and activation of NF-kappa B may be crucial in HTLV-I-induced IL-6 gene activation in ATL.
|
7949164 |
1994 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data may provide the prospect of the gene therapy for ATL by tax-targeted selective elimination of leukemic cells.
|
7919376 |
1994 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because clustering occurs with HTLV-I and ATL, members of ATL families were examined for antibodies to the tax protein and compared with matched HTLV-I-positive blood donors.
|
1984476 |
1991 |