|
Neuroblastoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
We then used genome-wide chromatin-immunoprecipitation coupled to high-throughput sequencing analysis to demonstrate that a small number of essential transcription factors-MYCN, HAND2, ISL1, PHOX2B, GATA3, and TBX2-are members of the transcriptional core regulatory circuitry (CRC) that maintains cell state in MYCN-amplified neuroblastoma.
|
30127528 |
2018 |
|
Neuroblastoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
To elucidate the underlying cellular mechanism of the TBX2-mediated repression of ADAM10 gene expression, we performed overexpression, RNAi-mediated knockdown and pharmacological inhibition studies in the human neuroblastoma cell line SH-SY5Y.
|
30599067 |
2019 |
|
Neuroblastoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we provide insight into the role of the TBX2 CRC gene in transcriptional dependency of neuroblastoma cells warranting clinical trials using BET and CDK7 inhibitors.
|
30451831 |
2018 |
|
Hypertensive disease
|
0.110 |
Biomarker
|
group |
BEFREE |
The role of TBX2 and TBX4 in pulmonary hypertension warrants investigation.
|
21271665 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, we showed that the TBX2 subfamily genes play a critical tumor suppressor role in lung cancer pathogenesis through regulating its methylating pattern, making them putative candidates for epigenetic therapy in LUAD.
|
30425966 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TBX2 overexpression correlated with tumor invasion, advanced tumor node metastasis stage and presence of lymph node metastasis.
|
30651856 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
S6K, PAT1, and TBX2 were coamplified in about 10% of tumors, whereas RADS1C amplification was seen in only 3% of tumors.
|
11034067 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TBX2 was a significantly prognostic factor for decreased survival and increased disease recurrence independent of tumor stage(II, III stage) and functioned as a biomarker to identify prognosis of patients with CRC (OS: HR 2.154; 95% CI 1.019-4.551; P = 0.044, DFS: HR 2.253; 95% CI 1.109-4.575; P = 0.025).
|
23959449 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma.
|
29719592 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The enriched genes included MMP9, SERPINE2, CAV1, KRT14, and RASA3 in basal tumors, and PPARG, LY6E, CTSE, CDK3, and TBX2 in luminal tumors.
|
30089113 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression level of Tbx2 had a significant positive relationship with tumor differentiation degree, higher TNM stage and distant metastasis.
|
19469638 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ChIP analysis and cell-based reporter assays further revealed that TBX2 directly represses transcription of E-cadherin, a tumor suppressor gene, whose loss is crucial for malignant tumor progression.
|
22844464 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Support for this hypothesis comes from studies demonstrating that many of the amplified genes are over-expressed in breast cancer cell lines and tumors, and that the RPS6KB1, TBX2, and PPM1D genes from the region, that are amplified and over-expressed in breast tumors and cell lines, contribute to tumor formation and/or tumor progression.
|
12755490 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high expression of TBX2 in NSCLC was significantly correlated with lymph node metastasis and tumor node metastasis (TNM) stage.
|
25027744 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
At the molecular level, we discovered that expressions of several tumor suppressor genes, including <i>p21, p27</i>, <i>phosphatase with tensin homology (PTEN)</i> and <i>E-Cadherin</i>, were increased dramatically after TBX2 knockdown in above NPC cells.
|
28881763 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Blocking endogenous TBX2 expression in PC3 and ARCaP<sub>M</sub> prostate cancer cell models using a dominant-negative construct resulted in decreased tumor cell proliferation, colony formation, and invasion <i>in vitro</i> Blocking endogenous TBX2 in human prostate cancer mouse xenografts decreased invasion and abrogation of bone and soft tissue metastasis.
|
28108510 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that the cancer cells expressing KAI1 attach to vascular endothelial cells through direct interaction between KAI1 and DARC, and that this interaction leads to inhibition of tumor cell proliferation and induction of senescence by modulating the expression of TBX2 and p21.
|
16862154 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.
|
12000749 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results indicated that the expression rates of TBX2 were significantly increased in the cancerous tissues, compared with the healthy tumor adjacent tissue, and TBX2 increased staining was associated with the clinical stage and pathological grade.
|
28849151 |
2017 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Finally, we show that TBX2 and CST6 displayed reciprocal expression in a cohort of primary breast cancers with increased TBX2 expression associating with increased metastases.
|
24742492 |
2014 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Gene network analyses suggested that MYC and TBX2 were the most significant upstream transcription factors in the breast cancers with high glucose uptake.
|
30777332 |
2019 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
T-box 2 (TBX2) is a transcription factor involved in mammary development and is known to be overexpressed in a subset of aggressive breast cancers.
|
20348948 |
2010 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
TBX2 is one of the family of genes encoding developmental transcription factors, characterized by a 200 amino acid DNA binding domain (T-box), found to be related to malignant phenotypes of mammary cancer.
|
19469638 |
2009 |
|
Malignant neoplasm of breast
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Moreover, our current and previous results emphasize the interaction between phenotype and genotype in BRCA1/2-related breast cancers and that a combination of morphologic features and alterations of ERBB2, MYC, and TBX2 may better define mechanisms of tumor progression, as well as determine which patients are more likely to carry BRCA1/2 mutations.
|
15236312 |
2004 |
|
Malignant neoplasm of breast
|
0.080 |
Biomarker
|
disease |
BEFREE |
TBX2 is preferentially amplified in BRCA1/2-associated breast cancers and TBX3 overexpression has been associated with advanced stage disease and estrogen-receptor-positive breast tumors.
|
23624936 |
2013 |