Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
For this purpose, we genotyped the schizophrenia-associated risk variants within zinc-finger protein 804A (ZNF804A), transcription-factor 4 and neurogranin in a large dyslexia case-control sample.
|
22781169 |
2012 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TCF4 variant was genotyped in 401 schizophrenia patients.
|
21228604 |
2011 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Biological insights from 108 schizophrenia-associated genetic loci.
|
25056061 |
2014 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, the results from our association and power analyses suggest that further research into the possible involvement of rare TCF4 sequence variants in schizophrenia risk is warranted by the assessment of larger cohorts with higher statistical power to identify rare variant associations.
|
26010163 |
2015 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Common variants conferring risk of schizophrenia.
|
19571808 |
2009 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
|
19571811 |
2009 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to assay the association of TCF4 single nucleotide polymorphisms (SNPs) with schizophrenia and the effect of these SNPs on phenotypic variability in schizophrenia in Southern Chinese Han Population.
|
31191620 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the expression levels of miR-137 and three candidate target genes (ZNF804A, CACNA1C, TCF4) in the DLPFC of postmortem brain tissue from 2 independent cohorts: (1) 26 subjects (10 control (CTR), 7 schizophrenia (SZ), 9 bipolar disorder (BD)) collected at the UCI brain bank; and (2) 99 subjects (33 CTR, 35 SZ, 31 BD) obtained from the Stanley Medical Research Institute (SMRI).
|
23786914 |
2013 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results imply that PPI might be modulated by four genotypes - COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 - indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
|
29287625 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced the 3'UTR of TCF4 in 13 multiplex schizophrenia families and 14 control families.
|
30771755 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
P50 suppression was significantly decreased in carriers of schizophrenia risk alleles of the TCF4 polymorphisms rs9960767, rs10401120rs, rs17597926, and 17512836 (P < 0.0002-0.00005).
|
22451930 |
2012 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
MGD |
|
|
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
|
31268507 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Risk genes associated with SZ at genome wide significance level (p value<7.2 × 10(-8)) include zinc finger binding protein 804A (ZNF804A), major histocompatibility (MHC) region on chromosome 6, neurogranin (NRGN) and transcription factor 4 (TCF4).
|
21946175 |
2012 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this review, we present a systematic bioinformatics and literature review of the genomics, biological function and interactome of TCF4 in the context of schizophrenia.
|
23129290 |
2013 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767.
|
24275585 |
2014 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we found that genes harboring de novo mutations in schizophrenia (P = 5.3 × 10-7), ASD (P = 2.5 × 10-4), and ID (P = 7.6 × 10-3) were also enriched among TCF4 targets.
|
29228394 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a SCZ risk variant in TCF4 is associated with neurophysiologic traits thought to index attention and working memory abnormalities in psychotic disorders.
|
24339136 |
2014 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.
|
19571808 |
2009 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TCF4 binding sites were modestly enriched among SCZ risk loci from the Psychiatric Genomic Consortium (OR = 1.56, P = 0.03).
|
29905862 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We observed no increase in frequency of larger alleles (>37 repeats) in affected individuals at SEF2-1B (BPAD: P=0.95, n= 100; SCZ: P=0.61, n=97) or at ERDA1 (BPAD: P= 0.4, n = 101; SCZ: P= 0.05, n = 151, with larger alleles more frequent in controls).
|
10395212 |
1999 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia.
|
31535015 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGRIP1L, NRGN, and TCF4) of the postmortem brain tissues of patients with schizophrenia and controls from two separate sample sets (i.e., the Australian Tissue Resource Center and Stanley Medical Research Institute).
|
24686180 |
2014 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
|
22688191 |
2012 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TCF4 is involved in neurodevelopment, and intergenic and intronic variants in or close to the TCF4 gene have been associated with susceptibility to schizophrenia.
|
22832956 |
2012 |