Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to assay the association of TCF4 single nucleotide polymorphisms (SNPs) with schizophrenia and the effect of these SNPs on phenotypic variability in schizophrenia in Southern Chinese Han Population.
|
31191620 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced the 3'UTR of TCF4 in 13 multiplex schizophrenia families and 14 control families.
|
30771755 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
|
31268507 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia.
|
31535015 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These were MUC21 for the broad depression phenotype with self-reported MDD and ZNF804A, MIR3143, PSORS1C2, STK19, SPATA31D1, RTN1 and TCF4 for the broad depression phenotype with schizophrenia.
|
30626913 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We show that dysregulation of multiple proteins in this pathway may be due to the combined effects of schizophrenia risk genes Tcf4, Tbr1, and Top3b.
|
31142819 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia.
|
31081034 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results imply that PPI might be modulated by four genotypes - COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 - indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
|
29287625 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we found that genes harboring de novo mutations in schizophrenia (P = 5.3 × 10-7), ASD (P = 2.5 × 10-4), and ID (P = 7.6 × 10-3) were also enriched among TCF4 targets.
|
29228394 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TCF4 binding sites were modestly enriched among SCZ risk loci from the Psychiatric Genomic Consortium (OR = 1.56, P = 0.03).
|
29905862 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we replicated the four European GWAS hits, miR-137-rs1625579 and three of its validated target gene loci SNPs (ZNF804a-rs1344706, CACNA1C-rs4765905 and TCF4-rs9960767) by genotyping in 2074 samples (schizophrenia cases-1005; controls-1069) from South Indian Population.
|
29599094 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.
|
29588831 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore the association of TCF4 and GRM8 gene polymorphisms with risk of SCZ.
|
30288643 |
2018 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data indicate effects of TCF4 perturbation on human cortical progenitor cell proliferation, a process that could contribute to cognitive deficits in individuals with Pitt-Hopkins syndrome and risk for schizophrenia.
|
27689884 |
2017 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In this study, we evaluated the association of transcription factor 4 (TCF4) gene mRNA level in peripheral blood with SCZ, and also its psychopathology, cognitive and intellectual impairments.
|
29105523 |
2017 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PKA phosphorylates TCF4 directly and a PKA phosphorylation site in TCF4 is necessary for its transcriptional activity in cultured neurons and in the developing brain <i>in vivo</i> We also demonstrate that <i>Gadd45g</i> (growth arrest and DNA damage inducible gamma) is a direct target of neuronal-activity-induced, TCF4-dependent transcriptional regulation and that TCF4 missense variations identified in SCZ patients alter the transcriptional activity of TCF4 in neurons.
|
28951451 |
2017 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
RNA-sequencing analyses of cortical and striatal micropunches from Brd1<sup>+/-</sup> and wild-type mice revealed differential expression of genes enriched for schizophrenia risk, including several schizophrenia genome-wide association study risk genes (e.g., calcium channel subunits [Cacna1c and Cacnb2], cholinergic muscarinic receptor 4 [Chrm4)], dopamine receptor D<sub>2</sub> [Drd2], and transcription factor 4 [Tcf4]).
|
27837920 |
2017 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the present study was to replicate the potential relationships between the TCF4 polymorphisms and SCZ.
|
27103199 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Also, pertinently, genome-wide association studies have shown a well-replicated association between TCF4 and SCZ.
|
27270050 |
2016 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The current study examined the interactive effects of TCF4 and AKT1 variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia.
|
27305091 |
2016 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, the results from our association and power analyses suggest that further research into the possible involvement of rare TCF4 sequence variants in schizophrenia risk is warranted by the assessment of larger cohorts with higher statistical power to identify rare variant associations.
|
26010163 |
2015 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and controls.
|
26343600 |
2015 |