TBX3, T-box transcription factor 3, 6926

N. diseases: 179; N. variants: 12
Disease: Acute respiratory failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.020 AlteredExpression disease BEFREE In addition to a role in development, TBX2 and TBX3 have been implicated in tumor development through downregulation of the alternative reading frame (ARF) tumor suppressor and an associated bypass of senescence. 15300007 2004
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.020 AlteredExpression disease BEFREE Results indicate that TBX3 represses expression of p14(ARF) tumor suppressor and that a HDAC inhibitor is able to reverse the TBX3 repressive function in a dosage-dependent manner. 18245468 2008