TBX3, T-box transcription factor 3, 6926

N. diseases: 179; N. variants: 12
Disease: Acute respiratory failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.020 AlteredExpression disease BEFREE Results indicate that TBX3 represses expression of p14(ARF) tumor suppressor and that a HDAC inhibitor is able to reverse the TBX3 repressive function in a dosage-dependent manner. 18245468 2008
CUI: C0264490
Disease: Acute respiratory failure
Acute respiratory failure 		0.020 AlteredExpression disease BEFREE In addition to a role in development, TBX2 and TBX3 have been implicated in tumor development through downregulation of the alternative reading frame (ARF) tumor suppressor and an associated bypass of senescence. 15300007 2004