|
Liver carcinoma
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
This indicates that the preferential expression from the large surface antigen promoter in the differentiated hepatoma cell lines is probably mediated by HNF1 or an HNF1-related transcription factor.
|
2157890 |
1990 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Expression of the same dominant negative mutant in human hepatoma HepG2 cells only partially inhibited endogenous LFB1 activity, due to stabilization of LFB1 dimers in these cells.
|
1331985 |
1992 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
It has been demonstrated that the hepatocyte nuclear factor 1 (HNF1) binding site is critical for the majority of the hepatitis B virus (HBV) large surface antigen promoter activity in differentiated hepatoma cell lines.
|
7931153 |
1994 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the extremely proximal promoter region of the AFP gene where glucocorticoid-responsive element and HNF-1 binding sites exist is not responsible for the re-expression of AFP in HCC.
|
7511984 |
1994 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellular carcinoma, five patients with hepatoblastoma, and 15 non-neoplastic liver tissues.
|
8912143 |
1996 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These findings show that poor histological differentiation of HCC correlates with decreases in the level and activity of HNF-1 alpha proteins.
|
9614379 |
1998 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs.
|
12355088 |
2002 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, among these four transcription factors, HNF-4 alpha and HNF-1 alpha expressions showed synchronism and had a close relation with HCC differentiation.
|
12967472 |
2003 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We identified hepatic nuclear factor 1 (HNF1) as an important liver-specific trans-acting element for the human ACAT2 gene using the human hepatocellular carcinoma cell lines HuH7 and HepG2.
|
15961790 |
2005 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The -803 G > A SNP influenced the transcription efficiency in a hepatocarcinoma cell line as well as the binding efficiency of hepatocyte nuclear factor 1 alpha to the motif.
|
17006670 |
2007 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Re-expression of HNF-1 in HCC cells reinduced MIA2 in HCC cells to similar levels as found in PHH.
|
17881540 |
2008 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver.
|
20041408 |
2010 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
HJV promoter analysis revealed potential HNF-1α and snail-binding sites, but functional analysis ruled out that these transcriptional regulators or promoter methylation are the cause of HJV downregulation in HCC.
|
21863061 |
2011 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Biallelic inactivating mutations of HNF1A have been frequently identified in hepatocellular adenomas (HCA), rare benign liver tumors usually developed in women under oral contraceptives, and in rare cases of hepatocellular carcinomas developed in non-cirrhotic liver.
|
21975049 |
2011 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Key features include metabolic alterations (induced by defects in HNF1A), oncogene-induced inflammation (activation of JAK-STAT signaling in inflammatory adenomas), and an association between activation of Wnt/β-catenin signaling and progression of HCAs in hepatocellular carcinomas.
|
23485860 |
2013 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Mutation analysis of HNF1A [encoding hepatocyte nuclear factor 1 (HNF1)α] was performed for L-FABP-negative HCC cases.
|
25516669 |
2014 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Thus, we identified a pathway in which TNFα-NF-κB signaling switches off negative regulation by suppressing HNF-1α-mediated expression of miR-194, revealing insight into the mechanisms linking inflammatory pathways, miRNA, and HCC metastasis.
|
26221053 |
2015 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our previous studies have demonstrated the therapeutic effects of HNF1α on hepatic fibrosis and hepatocellular carcinoma (HCC) in animals.
|
28547778 |
2017 |
|
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Further analyses revealed a key role of ERK leading to increased phosphorylation of p90-ribosomal S6 kinase (RSK) and a concomitant activation of ETS-like transcription factor-1(ELK1) and Death Receptor protein-5 (DR5) in HCC.
|
29263422 |
2017 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The expression in HA was variable and differed between molecular subtypes of this neoplasm: inflammatory and HNF1A mutation-associated type are characterized by overexpression of c-MET to an extent comparable with poorly-differentiated HCC, whereas Wnt/β-catenin dysfunction-associated type lacks overexpression, and the amount of c-MET protein accumulated in its cells is similar to the levels in non-neoplastic tissue and well- to moderately-differentiated HCC.
|
29256857 |
2017 |
|
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Among these lncRNAs, the expression levels of HNF1A-AS1 were notably correlated with HNF1α levels in HCC cells and human HCC tissues.
|
29466992 |
2018 |
|
Liver carcinoma
|
0.800 |
Therapeutic
|
disease |
RGD |
Among these lncRNAs, the expression levels of HNF1A-AS1 were notably correlated with HNF1α levels in HCC cells and human HCC tissues.
|
29466992 |
2018 |
|
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In this study, the point mutation of HNF1α gene with c.A1532 > T/p.Q511L was identified in an HCC patient by exon-capture high-throughput sequencing.
|
29101032 |
2018 |