HNF1A, HNF1 homeobox A, 6927

N. diseases: 292; N. variants: 105
Disease: Steatohepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.040 Biomarker disease BEFREE Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription. 28394260 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.040 GeneticVariation disease BEFREE HNF1α inactivating HCA is associated with bi-allelic mutations in the TCF1 gene and morphologically has marked steatosis. 25195525 2015
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.040 GeneticVariation disease BEFREE Hepatocellular adenomas (HCAs) containing inactivating HNF1a mutations correspond to a homogenous group of tumors with marked steatosis and no cytological abnormalities or inflammatory infiltrates. 21566527 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.040 GeneticVariation disease BEFREE Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1alpha (HNF1alpha) were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. 17379603 2007