|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
BEFREE |
Next-Generation Sequencing Approach in Methylation Analysis of HNF1B and GATA4 Genes: Searching for Biomarkers in Ovarian Cancer.
|
28241454 |
2017 |
|
ovarian neoplasm
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
|
28346442 |
2017 |
|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
BEFREE |
Previously, we have identified the Grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared with normal ovarian tissues.
|
28278050 |
2017 |
|
ovarian neoplasm
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer.
|
28214017 |
2017 |
|
ovarian neoplasm
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
|
ovarian neoplasm
|
0.190 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic inactivation of HNF1B in ovarian cancer also associates with known risk SNPs, with a similar impact on EMT.
|
27732966 |
2016 |
|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
BEFREE |
Collectively, in this study, we illustrated for the first time that HNF1B may contribute to drug resistance in ovarian cancer, potentially through the 4 pathways.
|
24968817 |
2014 |
|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
BEFREE |
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
|
23535649 |
2013 |
|
ovarian neoplasm
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
23535730 |
2013 |
|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
LHGDN |
TCF2 was methylated in 53% of ovarian cancer cell lines and 26% of primary ovarian cancers, resulting in loss of the gene's expression.
|
16479257 |
2006 |
|
ovarian neoplasm
|
0.190 |
Biomarker
|
disease |
LHGDN |
We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors.
|
17503391 |
2006 |
|
ovarian neoplasm
|
0.190 |
AlteredExpression
|
disease |
LHGDN |
Since nine of the potential HNF1beta target genes are deregulated in clear cell carcinoma of the ovary, we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern.
|
16297991 |
2005 |