HNF1B, HNF1 homeobox B, 6928

N. diseases: 279; N. variants: 72
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 Biomarker disease BEFREE Next-Generation Sequencing Approach in Methylation Analysis of HNF1B and GATA4 Genes: Searching for Biomarkers in Ovarian Cancer. 28241454 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 GeneticVariation disease BEFREE As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer. 28214017 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 PosttranslationalModification disease BEFREE Epigenetic inactivation of HNF1B in ovarian cancer also associates with known risk SNPs, with a similar impact on EMT. 27732966 2016
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 Biomarker disease BEFREE Collectively, in this study, we illustrated for the first time that HNF1B may contribute to drug resistance in ovarian cancer, potentially through the 4 pathways. 24968817 2014
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 Biomarker disease BEFREE Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. 23535649 2013
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 GeneticVariation disease GWASDB GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. 23535730 2013
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 Biomarker disease BEFREE These results suggest that TCF2 is involved in the development of ovarian cancers and may represent a useful target for their detection and treatment. 16479257 2006
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.170 AlteredExpression disease BEFREE Thus, vHNF1 regulates tissue-specific transcription in ovarian carcinoma. 12566316 2003