TCF3, transcription factor 3, 6929

N. diseases: 244; N. variants: 8
Disease: Diabetes Mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 AlteredExpression group BEFREE We have previously shown that diabetes causes an imbalance of nerve growth factor (NGF) isoforms resulting in accumulation of its precursor proNGF and upregulation of the p75 neurotrophin receptor (p75<sup>NTR</sup>), with consequent increases in the activation of Ras homologue gene family, member A (RhoA). 31073629 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 Biomarker group BEFREE Ablating the p75 neurotrophin receptor, which is present on sympathetic axons, prevents early sympathetic islet neuropathy (eSIN), but, interestingly, not diabetes. 25200302 2014
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 Biomarker group BEFREE The p75 neurotrophin receptor (p75(NTR)) contributes to diabetes mellitus-induced defective postischemic neovascularization. 23065828 2012
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 Biomarker group BEFREE Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles. 18566344 2008