|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D. It has been hypothesized that germline variants within the TCF7L2 gene previously associated with diabetes may affect cancer risk through the Wnt/beta-catenin signaling pathway.
|
18302196 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
|
27998387 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes.
|
18650481 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable.
|
20616309 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2).
|
23942764 |
2013 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the family-based study, variation in TCF7L2 increased the risk of diabetes about three-fold (HR 1.75 per allele, 95% CI 1.3-2.4; p = 0.0006), and decreased the mean age at diabetes diagnosis by 7 years.
|
19585101 |
2009 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the near future, large-scale genome-wide association studies will fully extend the genome coverage, potentially delivering other common diabetes-susceptibility genes like TCF7L2.
|
17476472 |
2007 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In this issue of the JCI, Lyssenko and colleagues report on their human and isolated islet studies and suggest that the risk allele increases TCF7L2 expression in the pancreatic beta cell, reducing insulin secretion and hence predisposing the individual to diabetes (see the related article beginning on page 2155).
|
17671643 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to confirm the effect of the TCF7L2 polymorphism rs7903146 on diabetes risk in a Brazilian population and to assess the use of this genetic marker in improving diabetes risk prediction in the general population.
|
19055834 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we discovered a previously unrecognized role for Tcf7l2, a transcription factor known as the canonical Wnt nuclear effector and diabetes risk-conferring gene, in establishing neuronal identity and circuits of the caudal forebrain.
|
28219675 |
2017 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
LADA shares genetic features with both type 1 (HLA, INS VNTR, and PTPN22) and type 2 (TCF7L2) diabetes, which justifies considering LADA as an admixture of the two major types of diabetes.
|
18310307 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles.
|
24906949 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Maternal GCK and TCF7L2 variants are associated with glucose levels known to carry an increased risk of adverse pregnancy outcome in women without overt diabetes.
|
20682688 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of 100K SNPs, one (rs7100927) was in moderate LD (r2 = 0.50) with TCF7L2 (rs7903146), and was associated with risk of diabetes (Cox p-value 0.007, additive hazard ratio for diabetes = 1.56) and with tFPG (GEE p-value 0.03).
|
17903298 |
2007 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our data indicate for the first time that TCF7L2 gene variants confer an increased risk for early impairment of glucose metabolism in obese children, which is consistent with adult studies identifying TCF7L2 as a major diabetes susceptibility gene.
|
17311858 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that patients with diabetes risk alleles in TCF7L2 have an altered hypoglycaemic response to SUs resulting in earlier secondary failure.
|
21349175 |
2011 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our findings thus propose a potential cellular mechanism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnormalities in the islet microenvironment in this disease.
|
29246974 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes.
|
18931037 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been associated with insulin sensitivity and diabetes, and the TCF7L2 gene is involved in the Wnt/beta-catenin signaling pathway, all factors thought to be important in the etiology of colon cancer.
|
18398040 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism predisposes to diabetes through modulation of beta-cell function and modulates lipid levels in familial dyslipidemia.
|
19105201 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes.
|
24128935 |
2013 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes.
|
24468095 |
2014 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
The transcription factor 7-like 2 (TCF7L2) has been recently associated with diabetes risk, and it may exert its effect through metabolic syndrome (MetS)-related traits and be subjected to modification by environmental factors.
|
19141698 |
2009 |