TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Rectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.030 AlteredExpression disease BEFREE The Wnt-transcription factor, TCF7L2, is overexpressed in primary rectal cancers that are resistant to chemoradiotherapy and TCF7L2 mediates resistance to chemoradiotherapy. 28811361 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.030 Biomarker disease BEFREE We recently reported overexpression of the Wnt transcription factor TCF4, also known as TCF7L2, in rectal cancers that were resistant to 5-fluorouracil-based chemoradiotherapy. 21983179 2011
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.030 GeneticVariation disease BEFREE To establish the role of human T Cell Factor-4 (hTCF-4) gene exons 3-9 mutation status in association with sporadic rectal cancer with microsatellite instability (MSI). 17659738 2007