TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Impaired insulin secretion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 Biomarker disease BEFREE The transcription factor T-cell factor 7-like 2 (TCF7L2) confers type 2 diabetes risk mainly through impaired insulin secretion, perturbed incretin effect and reduced beta-cell survival. 21965303 2012
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 GeneticVariation disease BEFREE The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest. 20107109 2010
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 GeneticVariation disease BEFREE Common variants in the TCF7L2 gene are associated with type 2 diabetes via impaired insulin secretion. 19183934 2009
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 GeneticVariation disease BEFREE The effect of TCF7L2 rs7903146 on glucose homeostasis is considered primarily due to impaired insulin secretion in European populations. 19509102 2009
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 AlteredExpression disease BEFREE In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion. 17671651 2007
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 GeneticVariation disease BEFREE Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. 17437080 2007
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.070 GeneticVariation disease BEFREE We studied whether a defect in the enteroinsular axis contributes to impaired insulin secretion in carriers of TCF7L2 polymorphisms. 17661009 2007