|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, SPRY4‑IT1 inhibition increased miR‑101 levels, resulting in downregulation of ZEB1/2 expression and thus exerting anti‑tumour effects in OS.
|
31746422 |
2020 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells.
|
30265649 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The findings of the current study indicated that ZEB1 was up-regulated in the OS tissues and cell lines, and that this up-regulation was inversely proportional to miR-409-3p expression levels.
|
30846940 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that MIAT functions by competing with critical RNAs to target miR-150-5p and activate zinc finger E-box binding homeobox 1 to modulate the function of osteosarcoma cells.
|
30655889 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we found that SIRT1-ZEB1-positive feedback enhanced the EMT process and metastasis of osteosarcoma.
|
30304565 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ZEB1 was upregulated in OS tissues; elevated ZEB1 expression was negatively correlated with the levels of miR‑708 expression.
|
30864726 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken these together, our findings in this study indicated that HOTAIR/miR-217/ZEB1 axis, as a novel research point can provide new insights into molecular mechanism of osteosarcoma development.
|
30367466 |
2019 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, SNHG16, miR-205, and ZEB1 interact in a common pathway during the development and occurrence of osteosarcoma, providing novel targets for intervention in the treatment of osteosarcoma.
|
30453308 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our research verified that suppression of CAT104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration, and invasion by regulating the expression of miR-381 and downstream ZEB1, as well as JNK and Wnt/β-catenin pathways.
|
29523223 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of ZEB1 reversed the effects of miR-340 on P-gp expression, cell viability, and apoptosis. miR-340 alleviated chemoresistance of OS cells by targeting ZEB1.
|
29494357 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our expression analyses confirm that Zeb1 is highly expressed in osteosarcoma specimens and cell lines.
|
30580326 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The correlation between zinc finger E-box-binding homeobox 1 (ZEB1) and Ovol2 was assessed using the luciferase gene reporter assay in the MG-63 and SW1353 cells and IHC in the human OS tissue samples.
|
29872308 |
2018 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-150 targeted ZEB1 to function as an antioncogenic regulator in OS.
|
28781686 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-429 may suppress the progression and metastasis of osteosarcoma by down-regulating the ZEB1 expression.
|
28694763 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, downregulation of ZEB1 by interference with small interfering RNA mimicked the effects of transfection with an miR‑130a mimic in OS.
|
28714003 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The intricate interactions between miR‑643 and ZEB1 may serve as a potential therapeutic target in osteosarcoma oncogenesis.
|
28849077 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vitro cultured osteosarcoma MG-63 cells were transfected with ZEB1 siRNA.
|
28387915 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Functional experiments showed that consistent with ZEB1-AS1 depletion, miR-200s overexpression and ZEB1 depletion both inhibit osteosarcoma cell proliferation and migration.
|
28075045 |
2017 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that busulfan may have an anti-osteosarcoma effect through downregulating ZEB1 and ZEB2 through activating the miR-200 family, highlighting a possibility of using busulfan as a novel therapy for osteosarcoma.
|
24815002 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, we discovered MiR-429 plays a role in osteosarcoma by binding the 3'UTR of zinc finger E-box-binding homeobox 1 (ZEB1) mRNA, and that overexpression of ZEB1 could reverse the proliferation, subsequently blocking effect of miR-429.
|
24633485 |
2014 |
|
Childhood Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of ZEB1 in osteosarcoma may be related to the carcinogenesis and development as well as metastasis and invasion of osteosarcoma.
|
22213004 |
2012 |
|
Childhood Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specificity of these antibodies was shown by Western blotting studies using siRNA mediated downregulation of SIP1 and ZEB1 in a human osteosarcoma cell line.
|
20515682 |
2010 |