TCF21, transcription factor 21, 6943

N. diseases: 143; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 AlteredExpression disease BEFREE <b>NEW & NOTEWORTHY</b> Transcription factor 21 (TCF21) is downregulated in cholangiocarcinoma (CCA) tissues or cells. 30920845 2019
CUI: C3888088
Disease: SMITH-MCCORT DYSPLASIA 1
SMITH-MCCORT DYSPLASIA 1
0.010 Biomarker disease BEFREE <b>Objective:</b> To better understand how TCF21 affects SMC phenotype, we sought to investigate the possible mechanisms by which it regulates the lineage determining myocardin (MYOCD)-serum response factor (SRF) pathway. 31815603 2020
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.500 Biomarker disease BEFREE Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. 26020946 2015
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.380 Biomarker disease BEFREE Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. 26020946 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.190 Biomarker disease BEFREE Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. 26020946 2015
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Pain control was better in ERAS (Visual analogue scale (VAS) POD1 (≥ 4) 19.0 vs. 39.3%, p = 0.017; VAS POD1 2.5 vs. 3.1, p = 0.010). 29234943 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Pain was significantly less on POD 1 in the PT group at the harvest site than at the recipient site (p < 0.001). 29769090 2018
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative
0.080 Biomarker phenotype BEFREE Postoperative pain scores (visual analog scale) and opioid usage (total morphine equivalents [TME] in milligrams) were compared temporally in the post-anesthesia care unit, postoperative day (POD) 0, POD 1, and following discharge. 30017719 2018
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.380 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.190 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
CUI: C0405580
Disease: Adrenal cortical hypofunction
Adrenal cortical hypofunction
0.010 Biomarker disease BEFREE Hypocortisolemia on POD1 (serum cortisol < 5 μg/dl) prompted a 7 am cortisol level measurement on POD 2 (POD2). 30835697 2019
CUI: C0030201
Disease: Pain, Postoperative
Pain, Postoperative
0.080 Biomarker phenotype BEFREE Postoperative pain was evaluated via a numerical scale (range = 0-10) immediately after surgery, before discharge to home, and on the first postoperative day (POD1). 31743284 2020
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.020 Biomarker group BEFREE TCF21 is known to regulate mesenchymal cell transition into epithelial cells, a property that has been shown to be deficient in carcinomas. 16415157 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE TCF21 hypermethylation in a variety of tumor cell lines suggests it may also be a valuable methylation biomarker in other tumor types. 20945327 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported functions in early lung and kidney development as well as tumor suppressor function in the malignancies of the lung and head and neck. 21771727 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.080 Biomarker group BEFREE Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported functions in early lung and kidney development as well as tumor suppressor function in the malignancies of the lung and head and neck. 21771727 2011
CUI: C0751571
Disease: Cancer of Urinary Tract
Cancer of Urinary Tract
0.010 Biomarker disease BEFREE TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. 21847011 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. 22862160 2012
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.030 Biomarker disease BEFREE Pod-1 construct inhibited the transcription of the Sf1/Luc reporter gene in a dose-dependent manner in mouse Y-1 adrenocortical carcinoma (ACC) cells, and inhibited endogenous SF-1 expression in the human H295R and ACC-T36 adrenocortical carcinoma cells. 23313103 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. 25156819 2015
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex
0.030 AlteredExpression group BEFREE POD-1/TCF21 may play a crucial role in adrenal and gonadal homeostasis and represses Sf-1/SF-1 expression in adrenocortical tumor cells. 26421305 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Transcription factor 21 (TCF21) functions as a tumor suppressor and is inactivated in several types of cancer. 27270650 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.080 Biomarker group BEFREE Transcription factor 21 (TCF21) functions as a tumor suppressor and is inactivated in several types of cancer. 27270650 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 Biomarker group BEFREE Transcription factor 21 (TCF21) functions as a tumor suppressor and is inactivated in several types of cancer. 27270650 2016
CUI: C0018818
Disease: Ventricular Septal Defects
Ventricular Septal Defects
0.010 GeneticVariation group BEFREE TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population. 28346832 2017