TCF21, transcription factor 21, 6943

N. diseases: 143; N. variants: 6
Disease: Coronary heart disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 AlteredExpression disease BEFREE TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression. 31014396 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE However, whether rs12190287 polymorphisms in the TCF21-3'UTR confer predisposition to congenital heart disease (CHD) is unclear. 28346832 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). 28059143 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. 26909569 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. 26020271 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 Biomarker disease BEFREE Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. 26020946 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease GWASCAT Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. 24262325 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2. 24676100 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease BEFREE Thus, both disease-related growth factor and embryonic signaling pathways may regulate CHD risk through two independent alleles at TCF21. 23874238 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease GWASDB Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. 21378990 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.190 GeneticVariation disease GWASCAT Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. 21378990 2011