BTK, Bruton tyrosine kinase, 695

N. diseases: 233; N. variants: 6
Disease: Arthritis ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003864
Disease: Arthritis
Arthritis 		0.130 Biomarker disease BEFREE In conclusion, B16 is a potent, selective and durable inhibitor of Btk and has the potential to a safe and efficacious treatment for arthritis. 29324347 2018
CUI: C0003864
Disease: Arthritis
Arthritis 		0.130 Biomarker disease BEFREE In the present work we extend this model to quantitatively correlate the engagement of Bruton's tyrosine kinase (Btk) by the covalent inhibitor CC-292 with the ability of this compound to reduce ankle swelling in an animal model of arthritis. 28507715 2017
CUI: C0003864
Disease: Arthritis
Arthritis 		0.130 Biomarker disease BEFREE Bruton's tyrosine kinase (Btk) is required for B lymphocyte and myeloid cell contributions to pathology in murine models of arthritis. 24764451 2015