BTK, Bruton tyrosine kinase, 695

N. diseases: 233; N. variants: 6
Disease: Lupus Nephritis ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.040 Biomarker disease BEFREE Overall, the significant efficacy of BI-BTK-1 in ameliorating multiple pathological endpoints associated with kidney disease in two distinct murine models of spontaneous lupus nephritis provides a strong rationale for BTK inhibition as a promising treatment approach for lupus nephritis. 30339790 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.040 Biomarker disease BEFREE The frequency of Btk+ B cells in the patients with LN was significantly higher than those without LN (p < 0.05). 28612243 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.040 Biomarker disease BEFREE Our results indicate that inhibition of BTK by HM71224 effectively reduced B cell hyperactivity and significantly attenuated the development of SLE and LN in rodent SLE models. 28950886 2017
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.040 Biomarker disease BEFREE SYK, BTK, PDGFR, EFGR, DDR1 and Janus kinase are implicated in the pathogenesis of lupus nephritis. 28391340 2017